Estrogen receptor has enhanced affinity for bromodeoxyuridine-substituted DNA. [PDF]
The estrogen receptor (E2R) from rabbit uterus has an enhanced affinity for BrdUrd-substituted DNA compared to unsubstituted DNA. Increasing levels of BrdUrd substitution (from 0 to 100%) in a DNA sample are associated with increasingly tighter binding of E2R to that DNA as measured by equilibrium competition experiments and by rates of dissociation ...
J, Kallos +3 more
openaire +2 more sources
The Hamiltonian of Einstein affine-metric formulation of General Relativity
It is shown that the Hamiltonian of the Einstein affine-metric (first order) formulation of General Relativity (GR) leads to a constraint structure that allows the restoration of its unique gauge invariance, four-diffeomorphism, without the need of any ...
A. Einstein +73 more
core +1 more source
A Large k Asymptotics of Witten's Invariant of Seifert Manifolds
We calculate a large $k$ asymptotic expansion of the exact surgery formula for Witten's $SU(2)$ invariant of Seifert manifolds. The contributions of all flat connections are identified. An agreement with the 1-loop formula is checked.
C. Lescop +12 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Self-adaptive encryption algorithm for image based on affine and composed chaos
On the basis of three-dimensional affine transformation in limited integer domain and composed chaos,a novel digital image encryption algorithm was proposed.Firstly,it scrambled pixels’ position and confused pixels’ value according to corresponding ...
Chang-ci WEN +4 more
doaj +2 more sources
Improved Vigenere approach incorporating pseudorandom affine functions for encrypting color images
This article presents an improvement to the traditional Vigenere encryption method, specifically adapted for the encryption of color images. This enhancement relies on the use of two chaotic maps widely employed in the field of cryptography.
Hamid El Bourakkadi +5 more
semanticscholar +1 more source
Algebraic Construction of Powerful Substitution Box
The development of wireless transmission, day by day contacts the new statures of innovation. Cryptography is one of the procedures used to give security to information streaming over the system by encryption and decryption. Substitution box (S-box) is a
E. W. Afify +6 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Improved vigenere using affine functions surrounded by two genetic crossovers for image encryption
This paper presents an improved method for encrypting color images, surpassing the effectiveness of genetic crossover and substitution operations. The technique incorporates dynamic random functions to enhance the integrity of the resulting vector ...
Hamid El Bourakkadi +5 more
semanticscholar +1 more source

