Results 51 to 60 of about 258,589 (319)
HLA-DRB1 alleles in four Amerindian populations from Argentina and Paraguay
Genetics and Molecular Biology, 2009 The major histocompatibility complex (MHC) is one of the biological systems of major polymorphisms. The study of HLA class II variability has allowed the identification of several alleles that are characteristic to Amerindian populations, and it is an ...
Maria L. Parolín, Francisco R. Carnese
doaj +1 more source
How to measure and evaluate binding affinities
eLife, 2020 Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models.
Inga Jarmoskaite +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Affine and degenerate affine BMW algebras: The center
Osaka Journal of Mathematics, 2011 The degenerate affine and affine BMW algebras arise naturally in the context of Schur-Weyl duality for orthogonal and symplectic Lie algebras and quantum groups, respectively. Cyclotomic BMW algebras, affine Hecke algebras, cyclotomic Hecke algebras, and their degenerate versions are quotients.
Daugherty, Z, Ram, A, Virk, R
openaire +5 more sources
Nature, 2003 Antibodies are the researcher's Swiss army knife: there's a tool for every purpose, and they're made in more shapes and sizes than ever. Pete Moore and Julie Clayton report.
Pete, Moore, Julie, Clayton
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
A Microfluidic Strategy to Capture Antigen‐Specific High‐Affinity B Cells
Advanced NanoBiomed ResearchAssessing B cell affinity to pathogen‐specific antigens prior to or following exposure could facilitate the assessment of immune status. Current standard tools to assess antigen‐specific B cell responses focus on equilibrium binding of the secreted ...
Ahmed M. Alhassan +8 more
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A presença de Nietzsche na obra de Foucault: mais do que uma afinidade filosófica [PDF]
Princípios, 2009 The references to Nietzsche proliferate in such a way along the almost thirty years of Foucault’s theoretical work that is evident the strong link between them.
Luiz Celso Pinho
doaj
Pb2+, Cu2+, Zn2+, Mg2+ and Mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro [PDF]
Archives of Biological Sciences, 2011 Flavone (Fl), genistein (Gen) and kaempferol (Kol) were studied for their affinities towards human serum albumin (HSA) in the presence and absence of Pb2+,Cu2+,Zn2+,Mg2+ and Mn2+.
Yang Fan +6 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source