Results 11 to 20 of about 1,150,504 (225)

Design and characterization of a protein fold switching network

Nature Communications, 2023
In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and likely ...
Biao Ruan, Yanan He, Yingwei Chen, Eun Jung Choi, Yihong Chen, Dana Motabar, Tsega Solomon, Richard Simmerman, Thomas Kauffman, D. Travis Gallagher, John Orban, Philip N. Bryan   +11 more
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Engineering subtilisin proteases that specifically degrade active RAS

Communications Biology, 2021
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity.
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan   +18 more
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Antibodies to SARS-CoV-2 and risk of past or future sick leave

Scientific Reports, 2021
The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. We invited all employees (n = 15,300) at work at the Karolinska University Hospital, Stockholm, Sweden to participate in a study examining SARS-Cov-2
Joakim Dillner, K. Miriam Elfström, Jonas Blomqvist, Carina Eklund, Camilla Lagheden, Sara Nordqvist-Kleppe, Cecilia Hellström, Jennie Olofsson, Eni Andersson, August Jernbom Falk, Sofia Bergström, Emilie Hultin, Elisa Pin, Anna Månberg, Peter Nilsson, My Hedhammar, Sophia Hober, Johan Mattsson, Laila Sara Arroyo Mühr, Kalle Conneryd Lundgren   +19 more
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Where are biomedical research plain‐language summaries?

Health Science Reports, 2020
Background and Aims Plain‐language summaries (PLS) are being heralded as a tool to improve communication of scientific research to lay audiences and time‐poor or nonspecialist healthcare professionals.
Hannah FitzGibbon, Karen King, Claudia Piano, Carol Wilk, Mary Gaskarth   +4 more
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Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers

Translational Neurodegeneration, 2020
Background The clinical presentations of frontotemporal dementia (FTD) are diverse and overlap with other neurological disorders. There are, as of today, no biomarkers in clinical practice for diagnosing the disorders.
Julia Remnestål, Linn Öijerstedt, Abbe Ullgren, Jennie Olofsson, Sofia Bergström, Kim Kultima, Martin Ingelsson, Lena Kilander, Mathias Uhlén, Anna Månberg, Caroline Graff, Peter Nilsson   +11 more
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Age-associated changes in intestinal health biomarkers in dogs

Frontiers in Veterinary Science, 2023
The gut microbiome is critical for maintaining host health. In healthy humans, the aging process is one of the main factors modulating the changes in the intestinal microbiota.
Anna Fernández-Pinteño, Rachel Pilla, Xavier Manteca, Jan Suchodolski, Celina Torre, Anna Salas-Mani   +5 more
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Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds

Alzheimer’s Research & Therapy, 2021
Background Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer’s disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate ...
Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Skoog, Peter Nilsson, Anna Månberg   +11 more
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Fat digestibility is reduced in old cats with subnormal cobalamin concentrations

Journal of Nutritional Science, 2014
Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility.
Anna Salas, Carmen-Loreto Manuelian, Marta Garganté, Núria Sanchez, Sonia Fernández, Marco Compagnucci, Jose Joaquín Cerón, Isabelle Jeusette, Lluís Vilaseca, Celina Torre   +9 more
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How Information Creates Its Observer: Emergence of the Information Observer with Regularities

Proceedings, 2022
Vladimir Lerner’s Information Macrodynamic (IMD) formalism is the first full application of John Archibald Wheeler’s “It from Bit” approach to physical Information processes.
Vladimir S. Lerner, Malcolm Dean
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Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Critical Care, 2021
Background Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process.
Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin   +8 more
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