Results 31 to 40 of about 2,297,328 (417)
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Proceedings of the National Academy of Sciences of the United States of America, 2008 Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug ...
C. Yun +7 more
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Deep Affinity Network for Multiple Object Tracking [PDF]
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2018 Multiple Object Tracking (MOT) plays an important role in solving many fundamental problems in video analysis and computer vision. Most MOT methods employ two steps: Object Detection and Data Association.
Shijie Sun +4 more
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Cortical development of AMPA receptor trafficking proteins
Frontiers in Molecular Neuroscience, 2012 AMPA-receptor trafficking plays a central role in excitatory plasticity, especially during development. Changes in the number of AMPA receptors and time spent at the synaptic surface are important factors of plasticity that directly affect long-term ...
Kathryn M Murphy +3 more
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Discovery of circulating proteins associated to knee radiographic osteoarthritis
Scientific Reports, 2017 Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for proteins that could serve as indicators ...
Lucía Lourido +9 more
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Affinely regular polygons in an affine plane
Contributions to Discrete Mathematics, 2008 In this paper we survey results about affinely regular polygons. First, the definitions and classification of affinely regular polygons are given. Then the theory of Bachmann-Schmidt is outlined. There are several classical theorems about regular polygons, some of them having analogues in finite planes, such as the Napoleon-Barlotti theorem.
KORCHMAROS, Gabor, SZONYI T.
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Binding Affinity via Docking: Fact and Fiction
Molecules, 2018 In 1982, Kuntz et al. published an article with the title “A Geometric Approach to Macromolecule-Ligand Interactions”, where they described a method “to explore geometrically feasible alignment of ligands and receptors of known structure”.
Tatu Pantsar, A. Poso
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Representations of Affine Multifunctions by Affine Selections [PDF]
Set-Valued Analysis, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Extreme disorder in an ultra-high-affinity protein complex
Nature, 2018 Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise complementarity of binding interfaces.
Alessandro Borgia +12 more
semanticscholar +1 more source
MeritsMedical doctors are at risk of poor mental health, linked to their working conditions. However, little distinction is made between private and public practice where working conditions differ.
Hannah Karrlein +5 more
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Frontiers in Neural Circuits, 2015 Although many potential neuroplasticity based therapies have been developed in the lab, few have translated into established clinical treatments for human neurologic or neuropsychiatric diseases.
Joshua G.A Pinto +4 more
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