Results 51 to 60 of about 2,330,138 (304)
Epidemiology of Dog and Cat Abandonment in Spain (2008–2013)
Animals, 2015 Millions of pets are abandoned worldwide every year, which is an important animal welfare and financial problem. This paper was divided into three studies.
Jaume Fatjó +6 more
doaj +1 more source
Clustering via kernel decomposition [PDF]
, 2006 Spectral clustering methods were proposed recently which rely on the eigenvalue decomposition of an affinity matrix. In this letter, the affinity matrix is created from the elements of a nonparametric density estimator and then decomposed to obtain ...
Girolami, M. +2 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Effect of thiols on beta 2-adrenoceptors in human mononuclear leucocytes [PDF]
, 1988 The effect of the disulfide reducing agent dithiothreitol (DTT) and other thiols on binding of the beta-adrenoceptor antagonist (-)-125iodocyanopindolol (125ICYP) to human mononuclear leucocytes (MNL) was investigated.
Anhäupl, T. +3 more
core
One Complete and Seven Draft Genome Sequences of Subdivision 1 and 3 Acidobacteria Isolated from Soil. [PDF]
, 2020 We report eight genomes from representatives of the phylum Acidobacteria subdivisions 1 and 3, isolated from soils. The genome sizes range from 4.9 to 6.7 Mb.
Clum, Alicia +16 more
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Pharmacology Research & Perspectives, 2022 α2‐adrenoceptors, (α2A, α2B and α2C‐subtypes), are Gi‐coupled receptors. Central activation of brain α2A and α2C‐adrenoceptors is the main site for α2‐agonist mediated clinical responses in hypertension, ADHD, muscle spasm and ITU management of sedation,
Richard G. W. Proudman +2 more
doaj +1 more source
Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]
, 2018 Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population
AnimalsThe gut and the gut microbiome communicate with the nervous system through the gut–brain axis via neuroimmune and neuroendocrine mechanisms. Despite existing research, studies exploring this link in aging dogs are limited.
Anna Fernández-Pinteño +6 more
doaj +1 more source