Results 61 to 70 of about 2,297,328 (417)
Regulation of protein-ligand binding affinity by hydrogen bond pairing
Science Advances, 2016 Receptor-ligand H-bond pairings have evolved to promote high-affinity binding by reducing competitive interference with water. Hydrogen (H)-bonds potentiate diverse cellular functions by facilitating molecular interactions.
Deliang Chen +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Theoretical Economics Letters, 2011 We propose a marriage model where assortative matching results in equilibrium for reasons other than those driving similar results in the search and matching literature. A marriage is a joint venture where husband and wife contribute to the couple’s welfare by allocating their time to portfolios of risky activities.
Daniela Di Cagno +2 more
openaire +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Pharmacology Research & Perspectives, 2022 α2‐adrenoceptors, (α2A, α2B and α2C‐subtypes), are Gi‐coupled receptors. Central activation of brain α2A and α2C‐adrenoceptors is the main site for α2‐agonist mediated clinical responses in hypertension, ADHD, muscle spasm and ITU management of sedation,
Richard G. W. Proudman +2 more
doaj +1 more source
Adaptive Affinity Fields for Semantic Segmentation [PDF]
European Conference on Computer Vision, 2018 Semantic segmentation has made much progress with increasingly powerful pixel-wise classifiers and incorporating structural priors via Conditional Random Fields (CRF) or Generative Adversarial Networks (GAN).
Tsung-Wei Ke +3 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population
AnimalsThe gut and the gut microbiome communicate with the nervous system through the gut–brain axis via neuroimmune and neuroendocrine mechanisms. Despite existing research, studies exploring this link in aging dogs are limited.
Anna Fernández-Pinteño +6 more
doaj +1 more source
Current applications of antibody microarrays
Clinical Proteomics, 2018 The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory detection and study of protein abundance ...
Ziqing Chen +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source