Results 81 to 90 of about 2,297,328 (417)
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19
Nature CommunicationsAutoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at five time ...
August F. Jernbom +12 more
doaj +1 more source
Biosensors, 2013 Two label-free biosensor platforms, Resonance Waveguide Grating (RWG) and Surface Plasmon Resonance (SPR), were used to rank a large panel of anti-dengue virus NS1 antibodies. Dengue non-structural 1 (NS1) protein is an established serological marker for
Joe Buechler +11 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Stability, affinity and chromatic variants of the glutamate sensor iGluSnFR
Nature Methods, 2018 Single-wavelength fluorescent reporters allow visualization of specific neurotransmitters with high spatial and temporal resolution. We report variants of intensity-based glutamate-sensing fluorescent reporter (iGluSnFR) that are functionally brighter ...
J. Marvin +21 more
semanticscholar +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Arthur Ransome and Dmitri Mitrokhin: Translating the Russian Folktale
Journal of Language and Education, 2016 This paper focuses on Arthur Ransome’s and Dmitri Mitrokhin’ s collaboration in translating the Russian folktales. Old Peter’s Russian Tales (1916), Ransome’ s first serious (and sustained) success, was the translation product of his early sojourns in ...
Tatiana Bogrdanova, Asya Usmanova
doaj +1 more source
Selecta Mathematica, 2006 The purpose of this work is to introduce a notion of \emph{affine stacks}, which is a homotopy version of the notion of affine schemes, and to give several applications in the context of algebraic topology and algebraic geometry. As a first application we show how affine stacks can be used in order to give a new point of view (and new proofs) on ...
openaire +2 more sources
Immunity, 2017 Summary How precursor frequencies and antigen affinities impact interclonal B cell competition is a particularly relevant issue for candidate germline‐targeting HIV vaccine designs because of the in vivo rarity of naive B cells that recognize broadly ...
Robert K. Abbott +12 more
semanticscholar +1 more source