Results 71 to 80 of about 2,330,138 (304)
APPLICATION OF REVERSE MOLECULAR DOCKING FOR THE IDENTIFICATION OF PROTEIN TARGETS OF S-ETHYLTHIOSULFANYLATE INVOLVED IN BIOSURFACTANT BIOSYNTHESIS [PDF]
Biotechnologia ActaAim. The study is focused on determining the effect of the ligand S-ethylthiosulfanylate on protein targets involved in the synthesis of biosurfactants and evaluating their potential interaction. Materials and Methods.
Yanvarov Y.B., Havryliak V.V.
doaj +1 more source
LIKWID: Lightweight Performance Tools [PDF]
, 2012 Exploiting the performance of today's microprocessors requires intimate knowledge of the microarchitecture as well as an awareness of the ever-growing complexity in thread and cache topology.
Hager, Georg +2 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Fluorescent Probes for Insect Ryanodine Receptors: Candidate Anthranilic Diamides
Molecules, 2014 Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe.
Yi Wang +8 more
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Improving binding affinity through cyclization [PDF]
, 2017 Cancer chemotherapy results in systematic damage as the drugs used are also toxic to benign tissue. Sensitizing a cancer cell to therapy by interfering with the DNA repair mechanisms would decrease overall toxicity, as the necessary dosage of ...
Abrigo, Nicolas, Newcomb, Kaylee M
core +1 more source
Incremental spectral clustering and its application to topological mapping [PDF]
, 2007 This paper presents a novel use of spectral clustering algorithms to support cases where the entries in the affinity matrix are costly to compute. The method is incremental – the spectral clustering algorithm is applied to the affinity matrix after each
Duckett, Tom +2 more
core +2 more sources
Journal of Combinatorial Theory, Series A, 1995 Let \({\mathbf P \mathbf G}(V)\) be an \((n + 1)\)-dimensional projective space arising from a right \((n + 2)\)-dimensional vector space over some skewfield \(D\). Let \(0 \leq k \leq n\) and let \({\mathcal H}\) be a collection of \(k\)-dimensional subspaces of \({\mathbf P \mathbf G} (V)\) with the property that for every \((k-1)\)-dimensional ...
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19
Nature CommunicationsAutoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at five time ...
August F. Jernbom +12 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source