Results 71 to 80 of about 2,297,328 (417)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Proof of concept of using a membrane-sensing peptide for sEVs affinity-based isolation
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: One main limitation in biomarker studies using EVs is the lack of a suitable isolation method rendering high yield and purity samples in a quick and easily standardized procedure.
Beatriz Benayas +10 more
doaj +1 more source
Review 1: "Protective Non-neutralizing mAbs Ab94 and Ab81 Retain High-affinity and Potent Fc-mediated Function Against SARS-CoV-2 Variants from Omicron to XBB1.5" [PDF]
, 2023 Sarah Caddy
openalex +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
APPLICATION OF REVERSE MOLECULAR DOCKING FOR THE IDENTIFICATION OF PROTEIN TARGETS OF S-ETHYLTHIOSULFANYLATE INVOLVED IN BIOSURFACTANT BIOSYNTHESIS [PDF]
Biotechnologia ActaAim. The study is focused on determining the effect of the ligand S-ethylthiosulfanylate on protein targets involved in the synthesis of biosurfactants and evaluating their potential interaction. Materials and Methods.
Yanvarov Y.B., Havryliak V.V.
doaj +1 more source
Affine and degenerate affine BMW algebras: The center
Osaka Journal of Mathematics, 2011 The degenerate affine and affine BMW algebras arise naturally in the context of Schur-Weyl duality for orthogonal and symplectic Lie algebras and quantum groups, respectively. Cyclotomic BMW algebras, affine Hecke algebras, cyclotomic Hecke algebras, and their degenerate versions are quotients.
Daugherty, Z, Ram, A, Virk, R
openaire +5 more sources
Nature, 2003 Antibodies are the researcher's Swiss army knife: there's a tool for every purpose, and they're made in more shapes and sizes than ever. Pete Moore and Julie Clayton report.
Pete, Moore, Julie, Clayton
openaire +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Fluorescent Probes for Insect Ryanodine Receptors: Candidate Anthranilic Diamides
Molecules, 2014 Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe.
Yi Wang +8 more
doaj +1 more source