Results 71 to 80 of about 1,578,929 (319)
HELIN Serials Affinity Group minutes for 10/1/10
Minutes of the Serials Affinity Group of the HELIN Consortium for October ...
HELIN Consortium. Serials Affinity Group
core
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The purpose of this work is to introduce a notion of \emph{affine stacks}, which is a homotopy version of the notion of affine schemes, and to give several applications in the context of algebraic topology and algebraic geometry. As a first application we show how affine stacks can be used in order to give a new point of view (and new proofs) on ...
openaire +2 more sources
HELIN Serials Affinity Group minutes for 03/12/13
Minutes of the Serials Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Serials Affinity Group
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
HELIN Cataloging Affinity Group minutes for 1/13/14
Minutes of the Cataloging Affinity Group of the HELIN Consortium for January ...
HELIN Consortium. Cataloging Affinity Group
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
HELIN Cataloging Affinity Group minutes for 03/14/12
Minutes of the Cataloging Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Cataloging Affinity Group
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
HELIN Acquisitions Affinity Group minutes for 3/24/14
Minutes of the Acquisitions Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. Acquisitions Affinity Group
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