Results 11 to 20 of about 141,574 (252)

Development of an affordability assessment framework for defence contracts at the bidding stage [PDF]

open access: yes, 2011
Defence contracting has changed from the traditional provision of spares and repairs to contracting long-term for availability and capability. In these long-term contracts, the customer decides to outsource services (that would have been provided in ...
Bankole, O. O.
core   +7 more sources

Urban housing affordability and housing policy dilemmas in Nigeria [PDF]

open access: yes, 2009
Given the increasing importance of affordability in housing policy reform debates, this study develops a new composite approach to measuring housing affordability and employs it to examine the nature of urban housing affordability in Nigeria.
Ndubueze, Okechukwu Joseph
core   +7 more sources

Utility payments in Ukraine: affordability, subsidies and arrears [PDF]

open access: yes, 2008
Transition has led to a significant increase in the severity and incidence of poverty in Eastern Europe. One important aspect of poverty is access to, and the affordability of, basic services like electricity, heat and water. This paper provides evidence
Falcetti, Elisabetta   +5 more
core   +1 more source

Prescription Drug Affordability Board newsletter

open access: yes, 2022
Oregon Prescription Drug Affordability Board.Covers OCLC #1356823819, OCLC #1375385138This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Miami Affordability Project Technical Document [PDF]

open access: yes, 2020
The Miami Affordability Project (MAP) is an interactive online map providing data on the distribution of affordable housing, housing needs, demographic profiles, and environmental resiliency in greater Miami.
University of Miami Office of Civic and Community Engagement
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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