Results 21 to 30 of about 1,912 (211)

The role of new inflammatory markers in determining disease activation and severity in patients with hidradenitis suppurativa

International Journal of Dermatology, Volume 62, Issue 8, Page 1076-1081, August 2023., 2023
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disease. Recently published studies have suggested the use of markers of inflammation to monitor HS patients. These studies discuss the platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), pan‐immune‐inflammation value (PIV), and systemic immune‐inflammation index (SIII ...
Eda Öksüm Solak, Burcu Baran Ketencioglu, Salih L. Cinar, Demet Kartal, Murat Borlu   +4 more
wiley   +1 more source

Management of rare inherited bleeding disorders: Proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders

European Journal of Haematology, Volume 110, Issue 6, Page 584-601, June 2023., 2023
Abstract Introduction The rare coagulation disorders may present significant difficulties in diagnosis and management. In addition, considerable inter‐individual variation in bleeding phenotype is observed amongst affected individuals, making the bleeding risk difficult to assess in affected individuals.
Marc Trossaert, Valerie Chamouard, Christine Biron‐Andreani, Alessandro Casini, Philippe De Mazancourt, Emmanuelle De Raucourt, Nicolas Drillaud, Birgit Frotscher, Benoit Guillet, Aurelien Lebreton, Valerie Roussel‐Robert, Lucia Rugeri, Yesim Dargaud   +12 more
wiley   +1 more source

Cellulitis on face in a patient with congenital afibrinogenemia

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2011
Congenital afibrinogenemia is a rare coagulation disorder, with an estimated prevalence of 1 : 1,000,000, characterized by a complete absence to reduced level of circulating fibrinogen.
G D Chandan, A G Annaji, S Bhatnagar, U Mohandas, P Dave   +4 more
doaj   +1 more source

Physiological correction of hereditary mild hypofibrinogenemia during pregnancy

Haemophilia, Volume 29, Issue 3, Page 836-843, May 2023., 2023
Abstract Introduction Hereditary hypofibrinogenemia is a rare fibrinogen disorder characterised by decreased levels of fibrinogen. Pregnant women with hypofibrinogenemia are at risk of adverse obstetrical outcomes, depending on the fibrinogen level.
Rita Marchi, Stéphane Durual, Océane Pecheux, Marguerite Neerman‐Arbez, Alessandro Casini   +4 more
wiley   +1 more source

Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency

Thrombosis Journal, 2018
Background Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur upon replacement therapy ...
S. Le Quellec, A. Desjonqueres, L. Rugeri, H. Desmurs Clavel, F. Farhat, L. Mechtouff, Y. Dargaud   +6 more
doaj   +1 more source

Integrating Next-Generation Sequencing Into Routine Molecular Diagnosis of Inherited Coagulation Factor Deficiencies: Real-World Data From Spanish Patients. [PDF]

Haemophilia
ABSTRACT Introduction Inherited coagulation factor deficiencies (ICFD) result from plasma protein deficiencies, impacting blood coagulation cascade and leading to haemorrhagic diathesis. Advancements in next‐generation sequencing (NGS) technology have enabled high‐throughput methods for molecular ICFD diagnosis.
Borràs N, Comes N, Ramírez L, Parra R, Altisent C, Lorenzo-Vizcaya Á, Marzo-Alonso C, López-Fernández MF, Canaro M, Falcón-Rodríguez M, Cortes-Vidal Á, Rios de Paz MA, Rodríguez-García JA, Moreto-Quintana A, Bandini P, Hobeich C, Corrales I, Vidal F.   +17 more
europepmc   +2 more sources

Pseudohomozygous dysfibrinogenemia

Research and Practice in Thrombosis and Haemostasis, 2021
Hypodysfibrinogenemia (HD) is a heterogeneous disorder in which plasma fibrinogen antigen and function are both reduced but discordant. This report addresses the key clinical question of whether genetic analysis enables clinically useful ...
Rachel C. Peck, Lucy Fitzgibbon, Christopher Reilly‐Stitt, Christopher Doherty, Emma Phillips, Andrew D. Mumford   +5 more
doaj   +1 more source

Addressing some challenges of congenital fibrinogen disorders in 2023 and beyond

Bleeding, Thrombosis and Vascular Biology, 2023
Congenital fibrinogen disorders (CFD) include several types and subtypes of fibrinogen deficiency, resulting from monoallelic or biallelic mutations in one of the three fibrinogen genes. While it is relatively easy to make an accurate diagnosis based on
Cristina Santoro, Alessandro Casini
doaj   +3 more sources

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]

, 1993
Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR, Nourshargh, S, Weg, VB, Williams, TJ   +3 more
core   +1 more source

Recurrent myocardial infarction in a case of congenital Afibrinogenemia

Heart Views, 2014
Afibrinogenemia is a rare autosomal recessive bleeding disorder with an estimated prevalence of 1:1,000,000. Usual presentation of this disorder is spontaneous bleeding, bleeding after minor trauma and excessive bleeding during interventional procedures.
Soumya Patra, Babu Reddy, C M Nagesh, B C Srinivas, C N Manjunath   +4 more
doaj   +1 more source