Incidence and risk factors of tocilizumab-induced hypofibrinogenemia in patients with thyroid eye disease: a single-center retrospective study [PDF]
Frontiers in EndocrinologyBackgroundTocilizumab, an interleukin-6 receptor antagonist, is increasingly used in moderate-to-severe thyroid eye disease. However, its association with hypofibrinogenemia remains underexplored in this population.MethodsThis single-center retrospective
Ente Wang +6 more
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Hereditary Hypofibrinogenemia with Hepatic Storage [PDF]
International Journal of Molecular Sciences, 2020 Fibrinogen is a 340-kDa plasma glycoprotein constituted by two sets of symmetrical trimers, each formed by the Aα, Bβ, and γ chains (respectively coded by the FGA, FGB, and FGG genes). Quantitative fibrinogen deficiencies (hypofibrinogenemia, afibrinogenemia) are rare congenital disorders characterized by low or unmeasurable plasma fibrinogen antigen ...
Rosanna Asselta +2 more
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Diagnostics, 2021 Congenital fibrinogen disorders are rare pathologies of the hemostasis, comprising quantitative (afibrinogenemia, hypofibrinogenemia) and qualitative (dysfibrinogenemia and hypodysfibrinogenemia) disorders. The clinical phenotype is highly heterogeneous,
Tomas Simurda +2 more
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Development and validation of a risk prediction model for tigecycline-induced hypofibrinogenemia in septic patients: a retrospective cohort study [PDF]
BMC Infectious DiseasesBackground Tigecycline is widely used in China to treat multidrug-resistant bacterial infections, with hypofibrinogenemia being the most common adverse effect due to its impact on coagulation.
Hongling Ma +4 more
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Risk Factors for Tigecycline-Associated Hypofibrinogenemia
Therapeutics and Clinical Risk Management, 2021 Jia Liu,1 Yingying Yan,2 Fan Zhang1 1Department of Geriatrics, Peking University Third Hospital, Beijing, People’s Republic of China; 2Department of Pharmacy, Peking University Third Hospital, Beijing, People’s Republic of ChinaCorrespondence:
Liu J, Yan Y, Zhang F
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Treatment effects of fibrinogen concentrates vs. cryoprecipitate for correcting hypofibrinogenemia in cardiac surgery patients: a systematic review and meta-analysis [PDF]
Frontiers in Cardiovascular MedicineBackgroundHypofibrinogenemia in cardiac surgery increases bleeding risk, but the efficacy and safety of fibrinogen concentrate vs. cryoprecipitate remain unclear.
Yue Chen +10 more
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The thrombotic paradox in congenital fibrinogen deficiencies: from pathophysiology to practice [PDF]
Research and Practice in Thrombosis and HaemostasisCongenital fibrinogen deficiencies (CFDs) comprise rare inherited disorders characterized by quantitative (afibrinogenemia, hypofibrinogenemia) or qualitative (dysfibrinogenemia, hypodysfibrinogenemia) abnormalities of fibrinogen.
Samin Mohsenian +2 more
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Identification of Risk Factors and Predictive Indicators for Tigecycline‐Associated Hypofibrinogenemia [PDF]
Clinical and Translational ScienceTo investigate the prevalence, clinical manifestations, and risk factors of hypofibrinogenemia after tigecycline use, which can disrupt coagulation and potentially hinder antimicrobial therapy.
Xiaohui Liu +5 more
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Acquired hypofibrinogenemia: current perspectives
Journal of Blood Medicine, 2016 Martin W Besser,1 Stephen G MacDonald2 1Department of Haematology, 2Department of Specialist Haemostasis, The Pathology Partnership, Addenbrooke’s Hospital, Cambridge, UK Abstract: Acquired hypofibrinogenemia is most frequently caused by ...
Besser MW, MacDonald SG
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Tigecycline-associated hypofibrinogenemia: A case report and review of the literature
IDCases, 2018 Tigecycline, a glycylcycline-derived antibacterial that has been approved for the treatment of various infections, is widely used for multi-drug resistant bacteria.
Chien-Chih Wu
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