Addressing some challenges of congenital fibrinogen disorders in 2023 and beyond
Bleeding, Thrombosis and Vascular Biology, 2023 Congenital fibrinogen disorders (CFD) include several types and subtypes of fibrinogen deficiency, resulting from monoallelic or biallelic mutations in one of the three fibrinogen genes. While it is relatively easy to make an accurate diagnosis based on
Cristina Santoro, Alessandro Casini
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Frontiers in Oncology, 2020 While cancer is often related to hyperfibrinogenemia, it is rarely related to hypofibrinogenemia. Specifically, gastric cancer concomitant with unprovoked hypofibrinogenemia and the corresponding treatment approach have been rarely reported. We presented
Shuzhen Ma +10 more
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Frontiers in Pharmacology, 2022 Background: Tigecycline was recently found to cause coagulation disorders, especially hypofibrinogenemia, which may interfere with the administration of antimicrobial therapy.
Bing Leng +15 more
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Pediatric Fibrinogen PART II—Overview of Indications for Fibrinogen Use in Critically Ill Children
Frontiers in Pediatrics, 2021 Bleeding is frequently seen in critically ill children and is associated with increased morbidity and mortality. Fibrinogen is an essential coagulation factor for hemostasis and hypofibrinogenemia is an important risk factor for bleeding in pediatric and
Gemma Louise Crighton +3 more
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PReS-FINAL-2041: Macrophage activation syndrome in the children with systemic juvenile idiopathic arthritis during the course of tocilizumab [PDF]
, 2013 Background Trauma exposure and posttraumatic stress disorder (PTSD) are common among individuals with a mental disorder, but symptoms often go undetected and untreated.
E Alekseeva +8 more
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Prediction of Post-Weaning Fibrinogen Status during Cardiopulmonary Bypass: An Observational Study in 110 Patients. [PDF]
, 2015 BACKGROUND: After cardiac surgery with cardiopulmonary bypass (CPB), acquired coagulopathy often leads to post-CPB bleeding. Though multifactorial in origin, this coagulopathy is often aggravated by deficient fibrinogen levels.
Alberio, L. +5 more
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Case Report: Co‐Occurrence of Lung Adenocarcinoma and Congenital Dysfibrinogenemia—Diagnostic and Perioperative Management Challenges [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Congenital dysfibrinogenemia (CD), a rare autosomal dominant coagulation disorder, poses significant perioperative challenges in oncologic surgery due to hypofibrinogenemia and variable bleeding‐thrombosis risks. Case A 67‐year‐old woman presented with a 2.9 × 1.4 cm spiculated mass in the right middle lobe (RML) and persistent ...
Zheng H +5 more
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Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature [PDF]
, 2015 Macrophage activation syndrome (MAS) is a potentially fatal condition. It is a rare complication of several autoimmune disorders, including systemic lupus erythematosus (SLE) and systemic juvenile idiopathic arthritis (sJIA).
Didona, Dario +4 more
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Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy. [PDF]
, 2016 Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver ...
Decker, Kerry A +5 more
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Women With Congenital Hypofibrinogenemia/Afibrinogenemia: From Birth to Death
Clinical and Applied Thrombosis/Hemostasis, 2020 Congenital fibrinogen disorders are a group of most frequent rare coagulation disorder, characterized by deficiency and/or defects in the fibrinogen molecule. Quantitative disorders include hypofibrinogenemia and afibrinogenemia.
Yan Zhang MD +2 more
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