Hereditary Hypofibrinogenemia with Hepatic Storage [PDF]
International Journal of Molecular Sciences, 2020 Fibrinogen is a 340-kDa plasma glycoprotein constituted by two sets of symmetrical trimers, each formed by the Aα, Bβ, and γ chains (respectively coded by the FGA, FGB, and FGG genes). Quantitative fibrinogen deficiencies (hypofibrinogenemia, afibrinogenemia) are rare congenital disorders characterized by low or unmeasurable plasma fibrinogen antigen ...
Rosanna Asselta +2 more
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Diagnostics, 2021 Congenital fibrinogen disorders are rare pathologies of the hemostasis, comprising quantitative (afibrinogenemia, hypofibrinogenemia) and qualitative (dysfibrinogenemia and hypodysfibrinogenemia) disorders. The clinical phenotype is highly heterogeneous,
Tomas Simurda +11 more
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Development and validation of a risk prediction model for tigecycline-induced hypofibrinogenemia in septic patients: a retrospective cohort study [PDF]
BMC Infectious DiseasesBackground Tigecycline is widely used in China to treat multidrug-resistant bacterial infections, with hypofibrinogenemia being the most common adverse effect due to its impact on coagulation.
Hongling Ma +4 more
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Acquired hypofibrinogenemia: current perspectives
Journal of Blood Medicine, 2016 Martin W Besser,1 Stephen G MacDonald2 1Department of Haematology, 2Department of Specialist Haemostasis, The Pathology Partnership, Addenbrooke’s Hospital, Cambridge, UK Abstract: Acquired hypofibrinogenemia is most frequently caused by ...
Besser MW, MacDonald SG
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Tocilizumab-induced hypofibrinogenemia in patients with systemic-onset juvenile idiopathic arthritis
Scientific Reports, 2023 Systemic juvenile idiopathic arthritis (SJIA) is a chronic inflammatory disease of childhood with elevated serum IL-6 levels. As an inhibitor of IL-6R, tocilizumab (TCZ) has been approved to treat SJIA patients.
Tingyan He, Jiayun Ling, Jun Yang
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Transient hypofibrinogenemia due to allopurinol
Drug Design, Development and Therapy, 2014 ZhiQiang Yin,1,* JiaLi Xu,2,* YongQiang Li,3,* JiPing Xia,1 Dan Luo1 1Department of Dermatology, 2Department of Oncology, 3Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's ...
Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D
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Physiological correction of hereditary mild hypofibrinogenemia during pregnancy
Haemophilia, 2023 Introduction: Hereditary hypofibrinogenemia is a rare fibrinogen disorder characterised by decreased levels of fibrinogen. Pregnant women with hypofibrinogenemia are at risk of adverse obstetrical outcomes, depending on the fibrinogen level.
Rita Marchi +2 more
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Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the FGB Gene [PDF]
Pediatric Reports, 2021 Detection of severe hypofibrinogenemia (
Jun Shinozuka +6 more
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Tigecycline-Associated Hypofibrinogenemia and Major Bleeding: Incidence, Predictors, and Clinical Outcomes in a Retrospective Cohort [PDF]
Infection and Drug ResistanceYu-Ting Huang,1,2 Jhih Syuan Yang,2 Yen-Ming Huang,1– 3 Yu-Ju Tseng,1,2 Fang-Ju Lin2– 4 1Department of Pharmacy, National Taiwan University Hospital, Taipei City, 100229, Taiwan; 2School of Pharmacy, College of Medicine, National Taiwan University ...
Huang YT +4 more
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Incidence and risk factors of tocilizumab-induced hypofibrinogenemia in patients with thyroid eye disease: a single-center retrospective study [PDF]
Frontiers in EndocrinologyBackgroundTocilizumab, an interleukin-6 receptor antagonist, is increasingly used in moderate-to-severe thyroid eye disease. However, its association with hypofibrinogenemia remains underexplored in this population.MethodsThis single-center retrospective
Ente Wang +6 more
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