Results 31 to 40 of about 6,740 (162)

First PATTEC consultative workshop on strategies, technical advances and partnerships in tsetse and trypanosomosis management

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2015
Tsetse and trypanosomiasis (T&T) remain endemic in many countries, although many efforts have been made in recent decades within the framework of the Pan-African Tsetse and Trypanosomiasis Eradication Campaign (PATTEC) Initiative, and despite progress ...
Hassane H. Mahamat
doaj   +1 more source

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [PDF]

Journal of Medicinal Chemistry, 2019
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy in some places because of the emergence of resistant ...
Giordani, Federica, Khalaf, Abedawn I., Gillingwater, Kirsten, Munday, Jane C., de Koning, Harry P., Suckling, Colin J., Barrett, Michael P., Scott, Fraser J.   +7 more
openaire   +6 more sources

The burden and spatial distribution of bovine African trypanosomes in small holder crop-livestock production systems in Tororo District, south-eastern Uganda

Parasites & Vectors, 2014
Background African animal trypanosomiasis (AAT) is considered to be one of the greatest constraints to livestock production and livestock-crop integration in most African countries.
Dennis Muhanguzi, Kim Picozzi, Jan Hattendorf, Michael Thrusfield, John David Kabasa, Charles Waiswa, Susan Christina Welburn   +6 more
doaj   +1 more source

Potential impacts of climate change on geographical distribution of three primary vectors of African Trypanosomiasis in Tanzania's Maasai Steppe: G. m. morsitans, G. pallidipes and G. swynnertoni.

PLoS Neglected Tropical Diseases, 2021
In the Maasai Steppe, public health and economy are threatened by African Trypanosomiasis, a debilitating and fatal disease to livestock (African Animal Trypanosomiasis -AAT) and humans (Human African Trypanosomiasis-HAT), if not treated.
Happiness Jackson Nnko, Paul Simon Gwakisa, Anibariki Ngonyoka, Calvin Sindato, Anna Bond Estes   +4 more
doaj   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

The transmission of African Animal Trypanosomiasis (Nagana) in two districts in the forest zone of Ghana [PDF]

, 2021
Abstract The African Animal Trypanosomiasis (nagana) is caused by several species of trypanosome species which results in significant clinical diseases. This consequently leads to huge economic losses. We carried out a cross-sectional survey to investigate the composition of vectors, parasite diversity and intensities
Austine Tweneboah, Jana Rosenau, Addo Kofi Agyapong, Thomas Kwame Addison, Mahamat Alhadj Moussa Ibrahim, Judith Sophie Weber, Soerge Kelm, Kingsley Badu   +7 more
openaire   +1 more source

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. Wenzler   +5 more
doaj   +1 more source

Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods

Vaccines, 2020
African animal trypanosomiasis is caused by vector-transmitted parasites of the genus Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and T. vivax in America and Asia.
Lucas Michel-Todó, Pascal Bigey, Pedro A Reche, María-Jesus Pinazo, Joaquim Gascón, Julio Alonso-Padilla   +5 more
doaj   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source