Results 61 to 70 of about 44,463 (262)

African Swine Fever Virus and Host Response: Transcriptome Profiling of the Georgia 2007/1 Strain and Porcine Macrophages

Journal of Virology, 2022
African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, with case fatality rates approaching 100% and no approved vaccines or antivirals.
G. Cackett, Raquel Portugal, D. Matelska, L. Dixon, F. Werner   +4 more
semanticscholar   +1 more source

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge

Journal of Virology, 2022
Currently, the deficiency in commercially available vaccines or therapeutic options against African swine fever constitutes a matter of major concern in the swine industry globally. Here, we report the design and construction of a recombinant ASFV mutant
Mingyang Ding, W. Dang, Hua-wen Liu, Fan Xu, Huaguo Huang, Yongjie Sunkang, Tao Li, Jingjing Pei, Xiang-tao Liu, Yong Zhang, Haixue Zheng   +10 more
semanticscholar   +1 more source

Clinical Validation of Two Recombinase-Based Isothermal Amplification Assays (RPA/RAA) for the Rapid Detection of African Swine Fever Virus

Frontiers in Microbiology, 2020
African swine fever (ASF), caused by African swine fever virus (ASFV), is a devastating infectious disease of domestic pigs and wild boars, and has tremendous negative socioeconomic impact on the swine industry and food security worldwide.
Xiaoxu Fan, Lin Li, Yonggang Zhao, Yutian Liu, Chunju Liu, Qinghua Wang, Yaqin Dong, Shujuan Wang, Tianying Chi, Fangfang Song, Chengyou Sun, Yingli Wang, Dengchuriya Ha, Yang Zhao, Yang Zhao, Jingyue Bao, Xiaodong Wu, Zhiliang Wang   +17 more
doaj   +1 more source

Transcriptome Profiling Reveals Features of Immune Response and Metabolism of Acutely Infected, Dead and Asymptomatic Infection of African Swine Fever Virus in Pigs

Frontiers in Immunology, 2021
African swine fever virus (ASFV) infection can result in lethal disease in pigs. ASFV encodes 150-167 proteins, of which only approximately 50 encoded viral structure proteins are functionally known. ASFV also encodes some nonstructural proteins that are
Hualin Sun, Qingli Niu, Jifei Yang, Yaru Zhao, Zhancheng Tian, Jie Fan, Zhonghui Zhang, Yiwang Wang, Shuxian Geng, Yulong Zhang, Guiquan Guan, David T. Williams, Jianxun Luo, Hong Yin, Hong Yin, Zhijie Liu   +15 more
doaj   +1 more source

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

Frontiers in Cellular and Infection Microbiology, 2022
African swine fever (ASF) is a devastating infectious disease caused by African swine fever virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity.
Yang-Yang Wang, S. Cui, T. Xin, Xixi Wang, Hainan Yu, Shiyu Chen, Yajun Jiang, Xintao Gao, Yitong Jiang, Xiaoyu Guo, H. Jia, Hongfei Zhu   +11 more
semanticscholar   +1 more source

Evaluation of Haematological and Immunological Parameters of the ASFV Lv17/WB/Rie1 Strain and Its Derived Mutant Lv17/WB/Rie1/d110-11L against ASFV Challenge Infection in Domestic Pigs

Vaccines, 2023
African swine fever virus (ASFV) is the etiological agent of a haemorrhagic disease that threatens the global pig industry. There is an urgency to develop a safe and efficient vaccine, but the knowledge of the immune–pathogenetic mechanisms behind ASFV ...
Giulia Franzoni, Stefano Petrini, István Mészáros, Silvia Dei Giudici, Cecilia Righi, Ferenc Olasz, Susanna Zinellu, Vivien Tamás, Michela Pela, Carmina Gallardo, Zoltán Zádori, Annalisa Oggiano, Francesco Feliziani   +12 more
doaj   +1 more source

Adaptive Cellular Immunity against African Swine Fever Virus Infections

Pathogens, 2022
African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs.
Alexander Schäfer, G. Franzoni, C. Netherton, L. Hartmann, S. Blome, U. Blohm   +5 more
semanticscholar   +1 more source

Unpicking the Secrets of African Swine Fever Viral Replication Sites

Viruses, 2021
African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral ...
Sophie-Marie Aicher, Paul Monaghan, Christopher L. Netherton, Philippa C. Hawes   +3 more
doaj   +1 more source

Thoughts on African Swine Fever Vaccines [PDF]

Viruses, 2021
African swine fever (ASF) is an acute viral hemorrhagic disease of domestic swine with mortality rates approaching 100%. Devastating ASF outbreaks and continuing epidemics starting in the Caucasus region and now in the Russian Federation, Europe, China, and other parts of Southeast Asia (2007 to date) highlight its significance.
openaire   +3 more sources

African Swine Fever Epidemiology and Control [PDF]

Annual Review of Animal Biosciences, 2020
African swine fever is a devastating disease that can result in death in almost all infected pigs. The continuing spread of African swine fever from Africa to Europe and recently to the high–pig production countries of China and others in Southeast Asia threatens global pork production and food security.
Dixon, Linda K., Ståhl, Karl, Jori, Ferran, Vial, Laurence, Pfeiffer, Dirk U.   +4 more
openaire   +5 more sources