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Pathogenicity and virulence of African swine fever virus [PDF]

Virulence
African swine fever (ASF) is a devastating disease with a high impact on the pork industry worldwide. ASF virus (ASFV) is a very complex pathogen, the sole member of the family Asfaviridae, which induces a state of immune suppression in the host through ...
Ines Ruedas-Torres, Bui Thi to Nga, Francisco J. Salguero   +2 more
doaj   +5 more sources

African Swine Fever Virus (ASFV): Immunity and Vaccine Development

Vaccines, 2023
African swine fever virus (ASFV) is the causative agent of the highly contagious disease African swine fever (ASF), which can result in mortality rates of up to 100% in pigs infected by virulent strains [...]
Kiramage Chathuranga, Jong-Soo Lee
doaj   +2 more sources

Characterization of a Novel African Swine Fever Virus p72 Genotype II from Nigeria

Viruses, 2023
African swine fever (ASF) is a high-consequence transboundary hemorrhagic fever of swine. It continues to spread across the globe causing socio-economic issues and threatening food security and biodiversity. In 2020, Nigeria reported a major ASF outbreak,
Aruna Ambagala, Kalhari Goonewardene, Lindsey Lamboo, Melissa Goolia, Cassidy Erdelyan, Mathew Fisher, Katherine Handel, Oliver Lung, Sandra Blome, Jacqueline King, Jan Hendrik Forth, Sten Calvelage, Edward Spinard, Douglas P. Gladue, Charles Masembe, Adeyinka J. Adedeji, Toyin Olubade, Nanven A. Maurice, Hussaini G. Ularamu, Pam D. Luka   +19 more
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Structural basis of RNA polymerase complexes in African swine fever virus [PDF]

Nature Communications
African swine fever virus is highly contagious and causes a fatal infectious disease in pigs, resulting in a significant global impact on pork supply.
Guoliang Zhu, Fei Xi, Wuxia Zeng, Yifei Zhao, Weijun Cao, Chen Liu, Fan Yang, Yi Ru, Shuqi Xiao, Shilei Zhang, Huanan Liu, Hong Tian, Fayu Yang, Biao Lu, Shukai Sun, Haiyang Song, Bozhang Sun, Xiaoyi Zhao, Lijie Tang, Kangli Li, Jijun He, Jianhong Guo, Yun Zhu, Zixiang Zhu, Fei Sun, Haixue Zheng   +25 more
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Detection of Recombinant African Swine Fever Virus Strains of p72 Genotypes I and II in Domestic Pigs, Vietnam, 2023

Emerging Infectious Diseases
African swine fever virus (ASFV) genotype II is endemic to Vietnam. We detected recombinant ASFV genotypes I and II (rASFV I/II) strains in domestic pigs from 6 northern provinces in Vietnam.
Van Phan Le, Van Tam Nguyen, Tran Bac Le, Nguyen Tuan Anh Mai, Viet Dung Nguyen, Thi Tam Than, Thi Ngoc Ha Lai, Ki Hyun Cho, Seong-Keun Hong, Yeon Hee Kim, Tran Anh Dao Bui, Thi Lan Nguyen, Daesub Song, Aruna Ambagala   +13 more
doaj   +2 more sources

Whole-genome sequencing of African swine fever virus from wild boars in the Kaliningrad region reveals unique and distinguishing genomic mutations

Frontiers in Veterinary Science, 2023
IntroductionSince the first report of outbreaks of African swine fever (ASF) in Georgia in 2007, the disease has expanded into Europe, Russia, and Asia, spreading rapidly via contact with infected animals including domestic pigs and wild boars.
Ali Mazloum, Antoinette van Schalkwyk, Antoinette van Schalkwyk, Andrey Shotin, Nikolay Zinyakov, Alexey Igolkin, Roman Chernishev, Zoran Debeljak, Fedor Korennoy, Alexander V. Sprygin   +9 more
doaj   +1 more source

Genetic Characterization of the Central Variable Region in African Swine Fever Virus Isolates in the Russian Federation from 2013 to 2017

Pathogens, 2022
African swine fever virus (ASFV), classified as genotype II, was introduced into Georgia in 2007, and from there, it spread quickly and extensively across the Caucasus to Russia, Europe and Asia. The molecular epidemiology and evolution of these isolates
Ali Mazloum, Antoinette Van Schalkwyk, Roman Chernyshev, Andrey Shotin, Fedor I. Korennoy, Alexey Igolkin, Alexander Sprygin   +6 more
doaj   +1 more source

Comparative Analysis of Full Genome Sequences of African Swine Fever Virus Isolates Taken from Wild Boars in Russia in 2019

Pathogens, 2021
In this study, we report on the full genome phylogenetic analysis of four ASFV isolates obtained from wild boars in Russia. These samples originated from two eastern and two western regions of Russia in 2019.
Ali Mazloum, Antoinette van Schalkwyk, Andrey Shotin, Alexey Igolkin, Ivan Shevchenko, Konstantin N. Gruzdev, Natalia Vlasova   +6 more
doaj   +1 more source

Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs

Viruses, 2022
African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine.
Lynnette C. Goatley, Rachel H. Nash, Catherine Andrews, Zoe Hargreaves, Priscilla Tng, Ana Luisa Reis, Simon P. Graham, Christopher L. Netherton   +7 more
doaj   +1 more source

A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

Emerging Microbes and Infections, 2023
African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease.
Wenming Liu, Hengchun Li, Bo Liu, T. Lv, Chenchen Yang, Si Chen, Liqiang Feng, L. Lai, Ziyuan Duan, Xinwen Chen, Pingchao Li, Suhua Guan, Ling Chen   +12 more
semanticscholar   +1 more source