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African Swine Fever Virus

2009
African swine fever virus (ASFV) is a large, intracytoplasmically-replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus-
E R, Tulman   +3 more
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Purification of African Swine Fever Virus

2022
African swine fever virus is a cytolytic virus that leads to the apoptosis of both cultured cells and primary macrophages. Cell culture supernatants of virus-infected cells are routinely used for virological and immunological studies, despite differences in the biological behavior between such preparations and highly purified virus.
Gareth L, Shimmon   +5 more
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Genotyping of African Swine Fever Virus

2022
Molecular methods are routinely used for the differential diagnosis and genetic characterization of viral diseases of livestock. Real-time PCR (qPCR) is known as the gold standard diagnostic method for most diseases and is also used for the detection of African swine fever virus (ASFV) DNA in clinical specimens.
Paulina, Rajko-Nenow, Carrie, Batten
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African Swine Fever Virus

2020
African swine fever virus introduction to naive swine population leads to high mortality and losses among susceptible animals. ASF epidemic in Russia (2007–to date) and lately in Eastern Europe highlights severe socio-economic consequences of this disease. The disease epidemiology is rather complex in endemic territories since many factors are involved
Alexander Malogolovkin   +2 more
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Diversity of African swine fever virus

American Journal of Veterinary Research, 1985
SUMMARY An African swine fever virus is an heterogeneous population, consisting of clones having different biological characteristics in respect to hemadsorption, virulence, infectivity, plaque size, and antigenic determinants. The following observations were made: (1) Nonhemadsorbing virus (nhv) have been segregated from field isolates from Haiti (ht ...
I C, Pan, W R, Hess
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African Swine Fever Virus

1985
African swine fever (ASF) was first described in 1921 by Montgomery, who reported several disease outbreaks of domestic pigs in Kenya since 1910 with a mortality close to 100%. Montgomery recognized the viral nature of the disease, its likely transmission by wild swine which probably acted as virus carriers, and the lack of protection by passive ...
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African swine fever virus attachment protein

Journal of Virology, 1991
Treatment of African swine fever virus particles with nonionic detergents released proteins p35, p17, p14, and p12 from the virion. Of these proteins, only p12 bound to virus-sensitive Vero cells but not to virus-resistant L or IBRS2 cells. The binding of p12 was abolished by whole African swine fever virus and not by similar concentrations of subviral
A L, Carrascosa, I, Sastre, E, Viñuela
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African Swine Fever Virus Host–Pathogen Interactions

2023
African swine fever virus is a complex double-stranded DNA virus that exhibits tropism for cells of the mononuclear phagocytic system. Virus replication is a multi-step process that involves the nucleus of the host cell as well the formation of large perinuclear sites where progeny virions are assembled prior to transport to, and budding through, the ...
Christopher L, Netherton   +4 more
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African swine fever virus interaction with microtubules

Biology of the Cell, 1993
Summary—The role of microtubules in intracellular transport of African swine fever virus (ASFV) and virus‐induced inclusions was studied by immunofluorescence using anti‐ASFV and anti‐tubulin antibodies, by electron microscopy of infected Vero cells and by in vitro binding of virions to purified microtubules.
A P, de Matos, Z G, Carvalho
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African Swine Fever Virus

1990
African swine fever is a devastating disease of swine caused by an icosahedral enveloped DNA virus which grows in the cytoplasm of infected cells. The virus infects domestic pigs and African or European wild boars, and can be transmitted by soft ticks.
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