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Epitopic diversity of African swine fever virus
Virus Research, 1988African swine fever (ASF) is caused by an icosahedral cytoplasmic, double stranded DNA virus. In the acute form of the disease, pigs die from disseminated intravascular coagulation (DIC) with extensive damage of the free and fixed macrophage systems and the reticular epithelial cells of the thymus; mortality is virtually 100%. In recent years, subacute
M. Shimizu +4 more
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Association of African swine fever virus with the cytoskeleton
Virus Research, 1988The association of African swine fever virus (ASFV) with the cytoskeleton was investigated. Immunofluorescent studies of ASFV infected cells with anti-ASFV serum showed a temporal and spatial development of viral inclusions which moved from a peripheral to a perinuclear location and fused to give a single large perinuclear factory.
A. P. Alves de Matos +2 more
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Interaction of African swine fever virus with macrophages
Virus Research, 1990Morphological data obtained by electron microscopy have shown that African swine fever virus adapted to VERO cells enters swine macrophages, its natural host cell, by a mechanism of receptor-mediated endocytosis. Binding studies with 3H-labeled virus and competition experiments with UV-inactivated virus have shown that the virus entry that leads to a ...
Eladio Viñuela +2 more
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Plaque Formation by African Swine Fever Virus
Nature, 1968FOLLOWING prolonged adaptation to cell cultures, several isolates of African swine fever virus (ASFV) produce cytopathic effects in pig kidney (PK) cells1–3. We have found that at least two such strains, Uganda3 and Hinde1, consistently produce plaques in monolayers of PK cells under solid overlays; this observation has led to the development of a ...
J. Parker, W. Plowright
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1990
African swine fever is a devastating disease of swine caused by an icosahedral enveloped DNA virus which grows in the cytoplasm of infected cells. The virus infects domestic pigs and African or European wild boars, and can be transmitted by soft ticks.
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African swine fever is a devastating disease of swine caused by an icosahedral enveloped DNA virus which grows in the cytoplasm of infected cells. The virus infects domestic pigs and African or European wild boars, and can be transmitted by soft ticks.
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A microtechnique for the titration for african swine fever virus
Archives of Virology, 1980African swine fever virus isolates were titrated in swine monocyte cultures established in microtitre trays. Although technically simpler and less laborious than conventional tube assays the microtitration assay was less sensitive, but for routine and comparative titrations offers distinct advantages.
R. C. Wardley, P. J. Wilkinson
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Unveiling African swine fever virus
Science, 2019Structural Virology African swine fever virus (ASFV) is highly contagious and often lethal. With no vaccine or effective treatment, infections often require large-scale culling of pigs. Wang et al. apply cutting-edge cryo–electron microscopy techniques to determine the structure of this very large DNA virus.
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Epidemiology of African Swine Fever Virus
1987African swine fever virus (ASFV), which prevails in Eastern and Southern Africa as a mild disease-causing agent in warthogs, found a most sensitive host in the domesticated pig. In the latter, ASFV affects the reticuloendothelial cells and causes the death of the host without a response from the immune system.
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African swine fever virus: on the move and dangerous
Veterinary Record, 2013AS the name suggests, African swine fever (ASF) has for many years been thought of as ‘one of those obscure diseases affecting pigs a long way off in Africa’ which do not pose a significant risk to pig populations in the UK and Europe. This was indeed the case up until the summer of 2007, when African swine fever virus (ASFV) appeared for the first ...
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African Swine Fever Virus in Nature
1987Thus far, natural infections with ASFV have been found only in porcine species and ticks of the genus Ornithodoros. In Africa, the virus has been recovered many times from warthogs (Phacochoerus aethiopicus) and bush pigs (Potamochoerus porcus), and they have also been infected experimentally (1, 2, 3).
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