Results 31 to 40 of about 28,486 (257)

African Swine Fever Virus F317L Protein Inhibits NF-κB Activation To Evade Host Immune Response and Promote Viral Replication

mSphere, 2021
African swine fever (ASF) is one of the most important pig diseases, causing a high case fatality rate and trade restrictions upon reported outbreaks. The limited understanding of the functions of the proteins of the causative agent, African swine fever ...
Jinping Yang, Shasha Li, Tao Feng, Xiangle Zhang, Fan Yang, Weijun Cao, Hongjun Chen, Huisheng Liu, Keshan Zhang, Zixiang Zhu, Haixue Zheng   +10 more
doaj   +1 more source

African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway

Journal of Immunology, 2021
Key Points ASFV MGF-505-7R inhibits cGAS–STING signaling. MGF-505-7R–deficient ASFV was fully attenuated in pigs at a dose of 10 HAD50. Visual Abstract African swine fever virus (ASFV) is a devastating infectious disease in pigs, severely threatening the
Dan Li, Wenping Yang, Lulu Li, Pan Li, Zhao Ma, Jing Zhang, X. Qi, Jingjing Ren, Yi Ru, Q. Niu, Zhijie Liu, Xiang-tao Liu, Haixue Zheng   +12 more
semanticscholar   +1 more source

Structure of African Swine Fever Virus and Associated Molecular Mechanisms Underlying Infection and Immunosuppression: A Review

Frontiers in Immunology, 2021
African swine fever (ASF) is an acute, highly contagious, and deadly infectious disease. The mortality rate of the most acute and acute ASF infection is almost 100%.
Yue Wang, W. Kang, Wenping Yang, Jing Zhang, Dan Li, Haixue Zheng   +5 more
semanticscholar   +1 more source

Riding apoptotic bodies for cell–cell transmission by African swine fever virus

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance ASFV is a leading threat to the world pork production and has evolved a mechanism to avoid antibody neutralization, contributing to viral persistence within infected pigs. We report here that ASFV highjacks the cellular efferocytosis pathway
Peng Gao, Lei Zhou, Jiajun Wu, Wenlian Weng, Hua Wang, Miaomiao Ye, Yajin Qu, Yuxin Hao, Yongning Zhang, X. Ge, Xin Guo, Jun Han, Hanchun Yang   +12 more
semanticscholar   +1 more source

Internal Validation of the ASFV MONODOSE dtec-qPCR Kit for African Swine Fever Virus Detection under the UNE-EN ISO/IEC 17025:2005 Criteria

Veterinary Sciences, 2023
African swine fever virus is considered an emerging virus that causes African swine fever, a disease characterised by high mortality and elevated transmission rates and that, as it is for most other viral diseases, cannot be treated with specific drugs ...
Gema Bru, Marta Martínez-Candela, Paloma Romero, Aaron Navarro, Antonio Martínez-Murcia   +4 more
doaj   +1 more source

Identification of a Continuously Stable and Commercially Available Cell Line for the Identification of Infectious African Swine Fever Virus in Clinical Samples

Viruses, 2020
African swine fever virus (ASFV) is causing outbreaks both in domestic pigs and wild boar in Europe and Asia. In 2018, the largest pig producing country, China, reported its first outbreak of African swine fever (ASF). Since then, the disease has quickly
Ayushi Rai, Sarah Pruitt, Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Ediane Silva, Lauro Velazquez-Salinas, Consuelo Carrillo, Manuel V. Borca, Douglas P. Gladue   +8 more
doaj   +1 more source

Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance African swine fever virus (ASFV) causes a severe and highly contagious disease in pigs and wild boars, but no commercial vaccines or antivirals are available currently.
Yuxuan Zheng, Su Li, Shihua Li, Shaoxiong Yu, Qihui Wang, Kehui Zhang, Liang Qu, Yuan Sun, Y. Bi, Fuchou Tang, H. Qiu, G. Gao   +11 more
semanticscholar   +1 more source

African Swine Fever Virus Guanylyltransferase

Virology, 1993
The gene coding for the guanylyltransferase of African swine fever virus has been identified and sequenced. The gene, designated NP868R, is located within fragments EcoRI N' and D of the virus genome (BA71V strain) and encodes a protein with a predicted molecular mass of 99.9 kDa that shares significant similarity with the large subunit of both ...
Pena, L., Yáñez, R. J., Revilla Novella, Yolanda, Viñuela, Eladio, Salas Falgueras, María Luisa   +4 more
openaire   +4 more sources

Autophagy impairment by African swine fever virus

Journal of General Virology, 2021
African swine fever is a devastating disease of domestic swine and wild boar caused by a large double-stranded DNA virus that encodes for more than 150 open reading frames. There is no licensed vaccine for the disease and the most promising current candidates are modified live viruses that have been attenuated by deletion of virulence factors.
Joshua Y. K. Hui, Christopher L. Netherton, Gareth Shimmon, Thomas Wileman, Thomas Wileman   +4 more
openaire   +5 more sources

Territorial pattern between outbreaks of ASF among wild and domestic pigs in Ukraine

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2021
The article presents the results of the analysis of the epizootic situation in Ukraine regarding African swine fever among domestic and wild pigs from 2012 to 2020 and identifies the main sources of virus spread as well as weak links in the biological ...
Ye. O. Dudnyk
doaj   +1 more source