Results 61 to 70 of about 2,609,022 (217)

The African swine fever virus isolate Belgium 2018/1 shows high virulence in European wild boar.

, 2020
African swine fever (ASF) is one of the most important and complex viral diseases in domestic pigs and wild boar. Over the last decade, the disease has spread to several European and Asian countries and is now one of the major threats to profitable pig ...
M.E. Schoder, A.Maria Gager, J. Sehl, A.Brigitte Cay, M. Tignon, S. Blome, J. Pikalo, A. Breithaupt, M. Beer, M. Fischer   +9 more
core   +1 more source

Attempts at the development of a recombinant African swine fever virus strain with abrogated EP402R, 9GL, and A238L gene structure using the CRISPR/Cas9 system

Journal of Veterinary Research, 2020
African swine fever (ASF) is a pressing economic problem in a number of Eastern European countries. It has also depleted the Chinese sow population by 50%.
Woźniakowski Grzegorz, Mazur-Panasiuk Natalia, Walczak Marek, Juszkiewicz Małgorzata, Frant Maciej, Niemczuk Krzysztof   +5 more
doaj   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

The intracellular proteome of African swine fever virus [PDF]

Scientific Reports, 2018
AbstractAfrican swine fever (ASF) is a viral disease that affects members of the Suidae family such as African bush pigs, warthogs, but also domestic pigs, and wild boar. It is transmitted by direct contact of naïve with infected animals, by soft ticks of the Ornithodoros genus, or indirectly by movement of infected animals, improper disposal of ...
Catharina Keßler, Jan H. Forth, Günther M. Keil, Thomas C. Mettenleiter, Sandra Blome, Axel Karger   +5 more
openaire   +2 more sources

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

The epidemiology of classical Swine Fever in West Timor, Indonesia [PDF]

, 2011
Classical swine fever (CSF) is a serious and highly infectious viral disease of domestic pigs and wild boar, which is caused by a single stranded RNA pestivirus. A cross sectional study was carried out on pigs owned by small-holder farmers in West Timor,
Malo Bulu, Petrus
core  

Prototype Biodiversity Digital Twin: Disease Outbreaks [PDF]

Research Ideas and Outcomes
African swine fever is a transmissible virus impacting wild and domestic swine populations. In Europe, it is non-native and the recently introduced genotype affects wild boar populations with occasional outbreaks in domestic pigs.
Kate Ingenloff, Syrine Ben Aziza, Claus Weiland, Nikoletta Nikolova, Hans-Hermann Thulke, Martin Lange, Adam Reichold, Dmitry Schigel   +7 more
doaj   +3 more sources

Successful Infection of Domestic Pigs by Ingestion of the European Soft Tick O. Erraticus That Fed on African Swine Fever Virus Infected Pig

Viruses, 2020
African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected
Rémi Pereira De Oliveira, Evelyne Hutet, Maxime Duhayon, Jean-Marie Guionnet, Frédéric Paboeuf, Laurence Vial, Marie-Frédérique Le Potier   +6 more
doaj   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source