Results 61 to 70 of about 8,652 (161)

CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects

open access: yesReviews in Medical Virology, Volume 35, Issue 6, November 2025.
ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency, characterised by impaired antibody production, immune dysregulation, and a broad spectrum of clinical manifestations. Gastrointestinal involvement is frequent, affecting up to 20% of patients and significantly contributing to morbidity and ...
Györgyi Műzes, Ferenc Sipos
wiley   +1 more source

JOINT DISEASE IN CHILDREN WITH X-LINKED AGAMMAGLOBULINEMIA

open access: yesJournal of IMAB, 2013
Patients with X-linked agammaglobulinemia (XLA) are prone to recurrent bacterial infections due to low levels of immunoglobulins. Clinical symptoms include recurrent bacterial otitis media, bronchitis, pneumonia, meningitis, skin infection and arthritis ...
Lidija Kareva   +2 more
doaj   +1 more source

Optimizing Lentiviral Vector Production: Insights Into PiggyBac Transposase and Concatemeric Array Strategies

open access: yesBiotechnology Journal, Volume 20, Issue 10, October 2025.
Graphical Abstract and Lay Summary Transposase‐mediated integration provides a robust alternative for generating stable lentiviral vector producer cell lines. While yielding slightly lower maximum titers than concatemeric‐array methods, it requires less DNA, accelerates recovery, and delivers more consistent performance, supporting scalable LVV ...
Jona Röscheise   +7 more
wiley   +1 more source

Duodenal nodular lymphoid hyperplasia in a patient with IgA deficiency

open access: yesClinical Case Reports, 2020
Most patients with IgA deficiency are asymptomatic, but duodenal nodular lymphoid hyperplasia is one symptom known to be associated with common variable immunodeficiency (CVID), including selective IgA deficiency and agammaglobulinemia.
Hanae Ida   +5 more
doaj   +1 more source

Immune System‐Related Genetic Risk Factors for Inhibitory Antibody Development in Patients With Hemophilia: Reviewing an Old Problem From a New Perspective—A Narrative Review

open access: yesHealth Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Hemophilia A and B are two of the most common bleeding disorders. Genetic risk factors are associated with the development of autoantibodies released in hemophilia patients against alternative factors and are the most important problems associated with the care of these patients. Objective In this study, we reviewed genetic
Fatemeh Zeylabi   +2 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

open access: yesVIEW, Volume 6, Issue 5, October 2025.
The recent advancements in the application of CRISPR/Cas9‐edited tumor‐associated immune cells in cancer therapy are summarized, including T lymphoid cells, natural killer cells, macrophages, and B lymphoid cells et al., exhibiting a potential impact on the pathological status of cancer. This review also addresses the current challenges associated with
Yuhui Ma   +6 more
wiley   +1 more source

A clinical case of autosomal recessive agammaglobulinemia with B-cell deficiency

open access: yesАллергология и Иммунология в Педиатрии
Background. Primary agammaglobulinemia is the result of specific changes in B-cells that lead to low antibody production. A preliminary diagnosis is established if there is a history of frequent bacterial infections (otitis media, sinusitis, skin ...
E. V. Negodnova   +4 more
doaj   +1 more source

Molecular diagnostics of primary immunodeficiencies in Sverdlovsk region

open access: yesМедицинская иммунология, 2021
The article presents the results of the work performed by the laboratory of molecular diagnostics at the Medical Center “Health Care of Mother and Child” for the diagnosis of primary immunodeficiency in Sverdlovsk region over 5 years.
S. S. Deryabina   +4 more
doaj  

Primera parte. Hombre de 45 años con neumonía grave, infección diseminada por citomegalovirus y agammaglobulinemia

open access: yesBiomédica: revista del Instituto Nacional de Salud
Se trata de un paciente de sexo masculino de 45 años con tos persistente de cuatro meses de duración, acompañada de fiebre y una significativa pérdida de peso.
Mónica Fernandes Pineda   +1 more
doaj   +1 more source

Agammaglobulinemia ligada A X Y onicodistrofia: dos nuevas mutaciones en el gen BTK y exclusión de mutaciones en el gen SOX9

open access: yesIatreia, 2010
La agammaglobulinemia ligada al cromosoma X ó Agammaglobulinemia de Bruton es una inmunodeficiencia que se caracteriza por ausencia de algunas inmunoglobulinas séricas, disminución de los linfocitos B tanto en la médula ósea como en la sangre periférica,
Carolina Rivera Nieto   +4 more
doaj  

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