Results 41 to 50 of about 18,379 (288)

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Fatal SARS in X-Linked Lymphoproliferative Disease Type 1: A Case Report

Frontiers in Pediatrics, 2022
X-linked lymphoproliferative disease (XLP1) is an inborn error of immunity (IEI) with severe immune dysregulation caused by a mutation in the SH2D1A gene resulting in the absence or dysfunction of signaling lymphocytic activation molecule (SLAM ...
Ming Hin Chung, Gilbert T. Chua, Daniel Leung, Koon Wing Chan, John Nicholls, Yu Lung Lau   +5 more
doaj   +1 more source

Haematopoietic Stem Cell Transplant for Norovirus-Induced Intestinal Failure in X-linked Agammaglobulinemia

Journal of Clinical Immunology, 2021
Since the first clinical description in 1952, immunoglobulin replacement therapy remains the mainstay of treatment of patients with X-linked agammaglobulinemia (XLA). However, this therapy only replaces IgG isotype and does not compensate for the loss of
B. Shillitoe, Mark J. Ponsford, M. Slatter, Jennifer A. Evans, S. Struik, M. Cosgrove, I. Doull, S. Jolles, A. Gennery   +8 more
semanticscholar   +1 more source

Optimization of immunoglobulin substitution therapy by a stochastic immune response model [PDF]

, 2009
Background: The immune system is a complex adaptive system of cells and molecules that are interwoven in a highly organized communication network. Primary immune deficiencies are disorders in which essential parts of the immune system are absent or do ...
Marc Thilo Figge, Derya Unutmaz, E Mix, CA Janeway, ICM MacLennan, T Manser, M Meyer-Hermann, MT Figge, L Marodi, OC Bruton, RH Buckley, HB Gaspar, D Vetrie, S Tsukadab, JS Orange, M Stangel, M Berger, MM Eibl, J Kirmse, A Gardulf, ML Moore, H Milgrom, J Bayry, AG MacGregor, H Fujikawa, JF Van Impe, M Peleg, AS Perelson, WH Press, H Risken, MD Kazatchkine, T Tha-In, J Bayry, V Hurez, S Kaveri, P Aukrust, J Andersson, T Jungi, M Stangel, T Takai, N Prasad, MT Figge   +41 more
core   +1 more source

Antibodies aggravate the development of ischemic heart failure [PDF]

, 2018
Heart-specific antibodies have been widely associated with myocardial infarction (MI). However, it remains unclear whether autoantibodies mediate disease progression or are a byproduct of cardiac injury. To disambiguate the role of immunoglobulins in MI,
Frantz, Stefan, Heinrichs, Margarete, Hofmann, Ulrich, Jocelyne, Demengeot, Keppner, Lea, Ramos, Gustavo, Rieckmann, Max   +6 more
core   +1 more source

Correction to: Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia: the Importance of an Early Diagnosis. [PDF]

J Clin Immunol
Blom M, Duintjer AJ, Jamee M, de Gier M, Bloomfield M, Klocperk A, Kralickova P, Karaca NE, Boyarchuk O, Čižnár P, Jeseňák M, Sharapova S, Skopovets E, Gonzalez-Granado LI, Palmeri S, Volpi S, Nalda AM, Tello SR, Soler-Palacín P, Abolhassani H, Pulvirenti F, Cinicola B, Wintergerst U, de Bree GJ, van den Berg JM, Leavis HL, Vermont C, Dalm VASH, van Aerde K, Henriet S, Jolink H, Potjewijd J, Lankester A, Mukherjee CR, Berghuis D, Pac M, Shillitoe BMJ, Gennery AR, van der Burg M.   +38 more
europepmc   +3 more sources

Genetic stability of Campylobacter coli in patients with primary antibody deficiencies [PDF]

, 2019
In the Clinical Communication, Dion et al 1 reported that in patients with severe primary antibody deficiency (PAD), Campylobacter infection is a major cause (6.5%) of chronic or recurrent diarrhea. Moreover, by a molecular study performed in a subset of
Milito, Cinzia, Quinti, Isabella
core   +1 more source

Presentation of a case of Bruton type primary agammaglobulinemia in Guinea

The Pan African Medical Journal, 2020
X-linked agammaglobulinemia (XLA) is a rare genetic disease caused by a mutation in the Bruton tyrosine kinase (BTK) gene. It is characterized by a profound deficiency of B cells and a decrease in all classes of immunoglobulins (Ig).
Kaba Condé, Hugues Ghislain Atakla, Mamadou Ciré Barry, Mohamed Lamine Condé, Malé Doré   +4 more
doaj   +1 more source

Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India

Frontiers in Immunology, 2021
Background There is paucity of literature on XLA from developing countries. Herein we report the clinical and molecular profile and outcome in a multicenter cohort of patients with XLA from India.
A. Rawat, A. Jindal, D. Suri, P. Vignesh, Anju Gupta, B. Saikia, R. Minz, A. Banday, R. Tyagi, K. Arora, Vibhu Joshi, Sanjib Mondal, Jitendra Kumar Shandilya, Madhubala Sharma, M. Desai, Prasad Taur, A. Pandrowala, V. Gowri, S. Sawantdesai, Maya Gupta, A. Dalvi, M. Madkaikar, A. Aggarwal, Revathi Raj, R. Uppuluri, S. Bhattad, Ananthvikas Jayaram, H. Lashkari, L. Rajasekhar, D. Munirathnam, M. Kalra, Anuj Shukla, Ruchi Saka, Rajni Sharma, R. Garg, K. Imai, S. Nonoyama, O. Ohara, P. Lee, Koon-wing Chan, Y. Lau, Surjit Singh   +41 more
semanticscholar   +1 more source

Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia [PDF]

, 2010
Mutations in Bruton's tyrosine kinase (BTK) gene are responsible for X-linked agammaglobulinemia (XLA), which is characterized by recurrent bacterial infections, profound hypogammaglobulinemia, and decreased numbers of mature B cells in peripheral blood.
OLIVEIRA JÚNIOR, E.B., RAMALHO, V.D., ROXO JÚNIOR, P., TANI, S.M., VILELA, M.M.S.   +4 more
core   +2 more sources