Results 51 to 60 of about 3,111 (258)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

School Climate and Teacher Attrition Intentions: A Case Study of Junior High Schools in Bole District, Ghana

Journal of Social and Scientific Education
Scholars have often alluded to factors influencing teacher attrition rates in schools, including inadequate compensation, limited career progression, excessive workload, lack of professional development, and poor work-life balance.
Agape Kanyiri
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

AGAPE: an experiment to detect Machos in the direction of the andromeda galaxy

, 1994
The status of the Agape experiment to detect Machos in the direction of the andromeda galaxy is presented.The status of the Agape experiment to detect Machos in the direction of the andromeda galaxy is ...
R. Ansari, P. Baillon, Kaplan, J., J.P. Picat, M. Aurière, J. Hecquet, P. Gondolo, J. Kaplan, Coutures, C., G. Coupinot, Auriere, M., Baillon, P., G. Soucail, Hecquet, J., Giraud-Heraud, Y., Melchior, A.L., C. Ghesquière, A. Bouquet, Y. Giraud‐Héraud, Moniez, M., A.L. Melchior, Gondolo, P., C. Coutures, M. Moniez, Ansari, R., Soucail, G., Coupinot, G., Picat, J.P., Bouquet, A., Ghesquiere, C.   +29 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Secular Agape: The Limits of Love in Botton and Rorty

Carthaginensia
The desire for cohesive communities marked by love seems to be latent in the human condition. The revolution brought about by the Judeo-Christian proposal seems to initiate a process in which this desire is realised.
Artur Ilharco Galvão
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Marina L. Infimate Collection

, 2023
Agape Ṭhiek, a female speaker of Ṭhiek from Retzawl village, gives consent for recording her and responds to questions about herself and her family, her choice of language in a social context, and her attitude towards Ṭhiek in relation to Hmar.
Infimate, Marina L.
core