Results 1 to 10 of about 4,246,910 (248)
TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide
Scientific Reports, 2021 Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad +4 more
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BMC Biology, 2022 Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and ...
Morag A. Lewis +15 more
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Body mass index in nursing home residents during the first year after admission
BMC Nutrition, 2023 Background Malnutrition - comprising both undernutrition and overweight - has to be addressed in the medical follow-up of older adults due to the negative consequences for the functional state and general health.
Corinna Vossius +8 more
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Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Scientific Reports, 2022 Immune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system is thought to cause a damaging invasion of immune ...
Hassan O. J. Morad +7 more
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Brain, Behavior, & Immunity - Health, 2022 Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms of chronic pain in this neurodegenerative disease is essential.
Rita Silva +4 more
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Informal and formal care among persons with dementia immediately before nursing home admission
BMC Geriatrics, 2020 Background Dementia is a care intensive disease, especially in the later stages, implying in many cases a substantial carer burden. This study assesses the use of formal and informal care resources among persons with dementia during the last month before
Arnt Egil Ydstebø +4 more
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BMC Geriatrics, 2021 Background With the evolving knowledge on hearing as a potentially modifiable mid-life risk factor for dementia, identification of people at risk becomes increasingly important.
Anna McDonough +5 more
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Nature Communications, 2023 Musculoskeletal chronic pain is prevalent in individuals with Alzheimer’s disease (AD); however, it remains largely untreated in these patients, raising the possibility that pain mechanisms are perturbed.
George Sideris-Lampretsas +7 more
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BMC Geriatrics, 2021 Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and ...
Miguel Germán Borda +10 more
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Frontiers in Aging Neuroscience, 2020 Objective: Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia. Yet, the domain-specific cognitive impairment of the mild cognitive impairment (MCI) phase of this disease (DLB-MCI) is still not been established ...
Mathilde Suhr Hemminghyth +4 more
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