Results 11 to 20 of about 18,303,252 (310)

Embedding audiological screening within memory clinic care pathway for individuals at risk of cognitive decline—patient perspectives

BMC Geriatrics, 2021
Background With the evolving knowledge on hearing as a potentially modifiable mid-life risk factor for dementia, identification of people at risk becomes increasingly important.
Anna McDonough, Joshi Dookhy, Cathy McHale, Jennifer Sharkey, Siobhan Fox, Sean P. Kennelly   +5 more
doaj   +1 more source

Curcumin in age-related diseases

Die Pharmazie, 2020
The world's aging population continues to grow at an unprecedented rate. Consequently, age-related diseases including diabetes and diabetic complication, neurodegenerative disease, cardiovascular disease have become a health problem that cannot be ignored. The purpose of this review is to summarize the benefits of curcumin for age-related diseases, and
Tang, Chunyin, Li, Luxin, Shi, Jiayi, Wu, Dan, Wang, Meng, Wu, Yan, Yuan, Xiaohuan   +6 more
openaire   +2 more sources

Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease

Nature Communications, 2023
Musculoskeletal chronic pain is prevalent in individuals with Alzheimer’s disease (AD); however, it remains largely untreated in these patients, raising the possibility that pain mechanisms are perturbed.
George Sideris-Lampretsas, Silvia Oggero, Lynda Zeboudj, Rita Silva, Archana Bajpai, Gopuraja Dharmalingam, David A. Collier, Marzia Malcangio   +7 more
doaj   +1 more source

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

BMC Geriatrics, 2021
Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and ...
Miguel Germán Borda, Luis Carlos Venegas-Sanabria, Elkin Garcia-Cifuentes, Ronald Camilo Gomez, Carlos Alberto Cano-Gutierrez, Diego Alejandro Tovar-Rios, Vera Aarsland, Khadija Khalifa, Alberto Jaramillo-Jimenez, Dag Aarsland, Hogne Soennesyn   +10 more
doaj   +1 more source

KCNQ channels regulate age-related memory impairment:KCNQ regulates age-related memory [PDF]

, 2013
In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and
Bilal R Malik, Malik, Bilal R., Cavaliere, Sonia, Malik, Bilal R, Bilal R. Malik (408687), James J. L. Hodge, Sonia Cavaliere, James J. L. Hodge (116854), Bilal R. Malik, Hodge, James J. L., James J L Hodge, Sonia Cavaliere (116850), Hodge, James J L   +12 more
core   +1 more source

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

Frontiers in Aging Neuroscience, 2020
Objective: Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia. Yet, the domain-specific cognitive impairment of the mild cognitive impairment (MCI) phase of this disease (DLB-MCI) is still not been established ...
Mathilde Suhr Hemminghyth, Luiza Jadwiga Chwiszczuk, Arvid Rongve, Arvid Rongve, Monica Haraldseid Breitve   +4 more
doaj   +1 more source

Mortality in nursing home residents stratified according to subtype of dementia: a longitudinal study over three years

BMC Geriatrics, 2022
Background There are several subtypes of dementia caused by different pathophysiology and with different clinical characteristics. Irrespective subtype, the disease is progressive, eventually leading to the need for care and supervision on a 24/7 basis ...
Corinna Vossius, Sverre Bergh, Geir Selbæk, Jūratė Šaltytė Benth, Janne Myhre, Eivind Aakhus, Bjørn Lichtwarck   +6 more
doaj   +1 more source

Modelling the Genetic Risk in Age-Related Macular Degeneration [PDF]

, 2012
Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians.
Weber, Bernhard H. F., Lars G. Fritsche, Weber, Bernhard H.F., Bernhard H. F. Weber, Grassmann, F., Iris M Heid, Grassmann, Felix, Lars G Fritsche, Fritsche Lars G., Keilhauer Claudia N., Keilhauer, Claudia N., Claudia N. Keilhauer, Claudia N. Keilhauer (162279), Heid, I.M., Heid, Iris M., Felix Grassmann, Felix Grassmann (162264), Fritsche, Lars G., Keilhauer, C.N., Claudia N Keilhauer, Iris M. Heid, Weber, B.H.F., Bernhard H F Weber, Grassmann Felix, Lars G. Fritsche (162272), Fritsche, L.G., Bernhard H. F. Weber (162289), Heid Iris M., Weber Bernhard H. F., Iris M. Heid (87553)   +29 more
core   +1 more source

Age-Related Variations in Takotsubo Syndrome

Journal of the American College of Cardiology, 2020
Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients.This study aimed to investigate age-related differences in TTS.Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age ...
Cammann V. L., Szawan K. A., Stahli B. E., Kato K., Budnik M., Wischnewsky M., Dreiding S., Levinson R. A., Di Vece D., Gili S., Citro R., Bossone E., Neuhaus M., Franke J., Meder B., Jaguszewski M., Noutsias M., Knorr M., Heiner S., D'Ascenzo F., Dichtl W., Burgdorf C., Kherad B., Tschope C., Sarcon A., Shinbane J., Rajan L., Michels G., Pfister R., Cuneo A., Jacobshagen C., Karakas M., Koenig W., Pott A., Meyer P., Roffi M., Banning A., Wolfrum M., Cuculi F., Kobza R., Fischer T. A., Vasankari T., Airaksinen K. E. J., Napp L. C., Dworakowski R., MacCarthy P., Kaiser C., Osswald S., Galiuto L., Chan C., Bridgman P., Beug D., Delmas C., Lairez O., Gilyarova E., Shilova A., Gilyarov M., El-Battrawy I., Akin I., Polednikova K., Tousek P., Winchester D. E., Galuszka J., Ukena C., Poglajen G., Carrilho-Ferreira P., Hauck C., Paolini C., Bilato C., Kobayashi Y., Shoji T., Ishibashi I., Takahara M., Himi T., Din J., Al-Shammari A., Prasad A., Rihal C. S., Liu K., Schulze P. C., Bianco M., Jorg L., Rickli H., Pestana G., Nguyen T. H., Bohm M., Maier L. S., Pinto F. J., Widimsky P., Felix S. B., Braun-Dullaeus R. C., Rottbauer W., Hasenfuss G., Pieske B. M., Schunkert H., Borggrefe M., Thiele H., Bauersachs J., Katus H. A., Horowitz J. D., Di Mario C., Munzel T., Crea F., Bax J. J., Luscher T. F., Ruschitzka F., Ghadri J. R., Opolski G., Templin C.   +108 more
openaire   +9 more sources

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

eLife, 2017
Transient receptor potential (TRP) ion channels in peripheral sensory neurons are functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of protein kinase mediated phosphorylation following activation of various G
Talisia Quallo, Omar Alkhatib, Clive Gentry, David A Andersson, Stuart Bevan   +4 more
doaj   +1 more source