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Pharmaceutics, 2019 A meeting organised by the Academy of Pharmaceutical Sciences focussed on the challenges of developing medicines for older adults. International experts discussed the complexity introduced by polypharmacy and multiple morbidities and how the risk–benefit ratio of a medicine changes as an individual ages.
John Wahlich +4 more
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TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide
Scientific Reports, 2021 Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad +4 more
doaj +1 more source
BMC Biology, 2022 Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Crispr, and ...
Morag A. Lewis +15 more
doaj +1 more source
Age-related autoimmunity [PDF]
BMC Medicine, 2013 Abstract Older persons have higher autoimmunity but a lower prevalence of autoimmune diseases. A possible explanation for this is the expansion of many protective regulatory mechanisms highly characteristic in the elderly. Of note is the higher production of peripheral T-regulatory cells.
Vadasz, Zahava +3 more
openaire +2 more sources
Body mass index in nursing home residents during the first year after admission
BMC Nutrition, 2023 Background Malnutrition - comprising both undernutrition and overweight - has to be addressed in the medical follow-up of older adults due to the negative consequences for the functional state and general health.
Corinna Vossius +8 more
doaj +1 more source
Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Scientific Reports, 2022 Immune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system is thought to cause a damaging invasion of immune ...
Hassan O. J. Morad +7 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2022 Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms of chronic pain in this neurodegenerative disease is essential.
Rita Silva +4 more
doaj +1 more source
Age-Related Lysosomal Dysfunctions
Cells, 2022 Organismal aging is normally accompanied by an increase in the number of senescent cells, growth-arrested metabolic active cells that affect normal tissue function. These cells present a series of characteristics that have been studied over the last few decades.
Guerrero-Navarro, Lena +2 more
openaire +3 more sources
Informal and formal care among persons with dementia immediately before nursing home admission
BMC Geriatrics, 2020 Background Dementia is a care intensive disease, especially in the later stages, implying in many cases a substantial carer burden. This study assesses the use of formal and informal care resources among persons with dementia during the last month before
Arnt Egil Ydstebø +4 more
doaj +1 more source
Epidemiology of Age-related Maculopathy [PDF]
Epidemiologic Reviews, 1995 IntroductionAge-related maculopathy, also referred to as senile or age-related macular degeneration, is the leading cause of permanent visual impairment among the elderly in western countries. Loss of vision results from the degeneration of the photoreceptors in the macular area; this occurs when the retinal pigment epithelium cells with which they are
Vingerling, J.R. +3 more
openaire +3 more sources