Results 101 to 110 of about 18,303,252 (310)

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain

Cell Reports, 2016
Chronic pain is a common and devastating condition that induces well-characterized changes in neurons and microglia. One major unanswered question is why these changes should persist long after the precipitating injury has healed.
Franziska Denk, Megan Crow, Athanasios Didangelos, Douglas M. Lopes, Stephen B. McMahon   +4 more
doaj   +1 more source

Health promotion intervention for people with early‐stage dementia: A quasi‐experimental study

Brain and Behavior, 2020
Introduction With the limited advancements in medical treatment, there is a growing need for supporting people with early‐stage dementia adjust to their diagnosis and improve their quality of life. This study aimed to investigate the effects of a 12‐week
Ingelin Testad, Martine Kajander, Martha T. Gjestsen, Ingvild Dalen   +3 more
doaj   +1 more source

Age-related changes of prevalence of thyroid dysgenesis.

, 2019
Age-related changes of prevalence of thyroid dysgenesis.
Hideki Hattori (7325933), Ken-ichi Nagasaki (5130728), Yuji Sunden (251928), Yaser Hosny Ali Elewa (5130725), Yasuhiro Kon (58978), Teppei Nakamura (466554), Osamu Ichii (339354), Tomoji Yoshiyasu (7325930), Osamu Tatsumi (5130731)   +8 more
core   +1 more source

PReventing and Approaching Crises for frail community-dwelling patients Through Innovative Care (PRACTIC): protocol for an effectiveness cluster randomised controlled trial

Trials
Background Demographic changes, with an increasing number and proportion of older people with multimorbidity and frailty, will put more pressure on home care services in municipalities.
Anette Væringstad, Ellen Thea Gjelseth Dalbak, Daniela Holle, Janne Myhre, Øyvind Kirkevold, Sverre Bergh, Bjørn Lichtwarck   +6 more
doaj   +1 more source

Mechanisms of age-related decline in memory search across the adult life span [PDF]

, 2013
Three alternative mechanisms for age-related decline in memory search have been proposed, which result from either reduced processing speed (global slowing hypothesis), overpersistence on categories (cluster-switching hypothesis), or the inability to ...
Hills, T., Samanez-Larkin, G., Hills, Thomas T., Mata, R. ; https://orcid.org/, Samanez-Larkin, Gregory R., Wilke, Andreas, Hills, Thomas Trenholm, Mata, Rui, Wilke, A.   +8 more
core   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

An organisation working mainly reactively instead of proactively: a qualitative study of how frail users of home care services and their next of kin experience crises

BMC Health Services Research
Background Frail people receiving home care services face an increased risk of developing crisis, which can result in adverse events, coercive measures, and acute institutionalisation.
Janne Myhre, Sverre Bergh, Øyvind Kirkevold, Bjørn Lichtwarck   +3 more
doaj   +1 more source

A retinoic acid receptor β agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord

Neurobiology of Disease, 2010
After spinal cord injury in the adult mammal, axons do not normally regrow and this commonly leads to paralysis. Retinoic acid (RA) can stimulate neurite outgrowth in vitro of both the embryonic central and peripheral nervous system, via activation of ...
Marta Agudo, Ping Yip, Meirion Davies, Elizabeth Bradbury, Patrick Doherty, Stephen McMahon, Malcolm Maden, Jonathan P.T. Corcoran   +7 more
doaj   +1 more source

Age-related increases in false recognition:The role of perceptual and conceptual similarity [PDF]

, 2014
Older adults are more likely to falsely recognize novel events than young adults, and recent behavioral and neuroimaging evidence points to a reduced ability to distinguish overlapping information due to decline in hippocampal pattern separation. However,
Morcom, Alexa, Laura M Pidgeon (16273007), Alexa Morcom (6188726), Morcom, Alexa M., Pidgeon, Laura Marie, Pidgeon, Laura M, Pidgeon, Laura M., Laura M. Pidgeon, Alexa M. Morcom, Morcom, Alexa M   +9 more
core   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source