Results 131 to 140 of about 18,303,252 (310)

Age-related disease or disease-related age? Perspectives for paleopathological research

ObjectiveThe interconnection of biological aging and disease throughout the life course profoundly affects almost every aspect of paleopathological research but is rarely explored. This paper presents a theoretical and practical framework for an informed
Niels Lynnerup (51145), Katherine D van Schaik (23253980), Fabian Crespo (23253983), Kathryn E Marklein (23253989), Molly Zuckerman (23253986), George R Milner (23253977), Joanna Appleby (6855860), Julia Gresky (7321145), Katharina Fuchs (551018), Marie Louise Schjellerup Jørkov (10788882)   +9 more
core   +2 more sources

De-2-hydroxyisobutyrylation of clusterin modulates neuropathology and memory deficits in an Alzheimer’s disease mouse model

Cell Communication and Signaling
Background Alzheimer’s disease (AD) is a progressive, irreversible neurodegenerative disorder with no effective cure, posing a major clinical challenge. Lysine 2-hydroxyisobutyrylation (Khib) is a recently identified post-translational modification found
Xiaoping Peng, Chaoyue Ouyang, Fubin Ma, Yu Liu, Lv Luo, Jiawei Xing, Sifan Feng, Li Li, Jiahao Zhang, Jiaying Wang, Helei Cheng, Tianying Zhang, Feng Chen, Yan Wang, Lili Cui   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Age-related inhibitory deficits in cognitive control of eye movements

, 2019
Age-related inhibitory deficits in cognitive control of eye ...
Rui Jin (105103), Larry Abel (13056207)
core   +1 more source

Altered Paths: Narrating Age-Related Memory Loss

Amnestic Mild Cognitive Impairment (aMCI), generally, is diagnosed when a person’s memory range is below that of what is expected of people their own age.
Alex Pickett
core  

Serum selenium levels are associated with age-related cataract

, 2018
Objective The aim of the study is to analyse correlations between age-related cataract (ARC), serum selenium levels and glutathione peroxidase gene 1 and 4 (GPX-1 and GPX-4). Material and methods A total sample of 275 participants were enrolled into the
Wojciech Lubiński, Karol Krzystolik, Michał Post, Magdalena Muszyńska, Piotr Baszuk, Wojciech Marciniak, Jan Lubiński   +6 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

APOE4 triggers dysregulated synaptic vesicle release by disrupting SNARE complex assembly

Cellular and Molecular Life Sciences
The ε4 allele of the Apolipoprotein E (APOE) gene is an important genetic risk factor for several neurodegenerative diseases, while the common pathogenic mechanism is still unclear.
Feng Chen, Yanting Chen, Sifan Feng, Huiyi Chen, Liehua Deng, Fubin Ma, Qiongwei Ke, Qiuhao Liang, Ji Chen, Xiaoping Peng, Jiongtong Lu, Yingxuan Liu, Yuying Xie, Hao Cao, Yuanhong Sun, Wenxian Wu, Lili Cui, Yan Wang   +17 more
doaj   +1 more source

Microscopic details of age related changes in rat optic nerve

, 2014
Age-related changes in the number and density of optic nerve fibres were studied in 12-month-old (adult) and 24- month-old (aged) male Wistar rats. Methods: Two-micrometer-thick resin-embedded optic nerve cross-sections obtained from two different age ...
PACELLA, Elena, Giulio De Paolis, Fernanda Pacella, Elena Pacella, CAVALLOTTI, Carlo, PACELLA, FERNANDA, Carlo Cavallotti, Maria Rosaria Carbotti, Roberto Muscella   +8 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source