Results 151 to 160 of about 4,246,910 (248)

AGE-RELATED RETINAL PIGMENT EPITHELIUM DISEASE: Clinical and Differential Features. [PDF]

Retina
Arrigo A, Aragona E, Antropoli A, Bianco L, Saladino A, Del Fabbro S, Bandello F, Parodi MB.   +7 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study

, 2011
Benny Almog, Fady Shehata, S. Suissa, Hananel Holzer, Einat Shalom‐Paz, Antonio La Marca, Shanthi Muttukrishna, Andrew S. Blazar, Richard Hackett, Scott M. Nelson, João Sabino Cunha‐Filho, Talia Eldar‐Geva, Ehud J. Margalioth, Nick Raine‐Fenning, Kannamannadiar Jayaprakasan, Myvanwy McIlveen, Dorothea Wunder, Thomas Fréour, Luciano G. Nardo, Juan Balasch, Joana Peñarrubia, J Smeenk, Christian Gnoth, Erhard Godehardt, Tsung‐Hsien Lee, Maw‐Sheng Lee, Ishai Levin, Ronni Gamzu, Togas Tulandi   +28 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Correction: Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms (TIME) in home care services: a cluster randomized feasibility trial

BMC Health Services Research, 2022
Kari-Anne Hoel, Bjørn Lichtwarck, Anette Væringstad, Ingvild Hjorth Feiring, Anne Marie Mork Rokstad, Geir Selbæk, Jūratė Šaltytė Benth, Sverre Bergh   +7 more
doaj   +1 more source

Age-Related Alterations of Cerebral Autoregulation. [PDF]

Life (Basel)
Ungvari A, Kállai A, Stankovics L, Lendvai-Emmert D, Gulej R, Pal E, Patai R, Csik B, Fekete M, Lipecz Á, Csípő T, Benyó Z, Csiszar A, Toth P.   +13 more
europepmc   +1 more source

Longitudinal segmentation of age-related white matter hyperintensities

, 2017
Carole H. Sudre, M. Jorge Cardoso, Sébastien Ourselin   +2 more
openalex   +1 more source

Age-Related Serum Thyroid-Stimulating Hormone Reference Range in Older Patients Treated with Levothyroxine: A Randomized Controlled Feasibility Trial (SORTED 1) [PDF]

, 2019
Salman Razvi, Vicky Ryan, Lorna Ingoe, Simon H. S. Pearce, Scott Wilkes   +4 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source