Results 11 to 20 of about 4,246,910 (248)

Mortality in nursing home residents stratified according to subtype of dementia: a longitudinal study over three years

BMC Geriatrics, 2022
Background There are several subtypes of dementia caused by different pathophysiology and with different clinical characteristics. Irrespective subtype, the disease is progressive, eventually leading to the need for care and supervision on a 24/7 basis ...
Corinna Vossius, Sverre Bergh, Geir Selbæk, Jūratė Šaltytė Benth, Janne Myhre, Eivind Aakhus, Bjørn Lichtwarck   +6 more
doaj   +1 more source

Data for “Oxidative stress is inhibited by plant-based supplements: a quantitative lipidomic analysis of antioxidant activity and lipid compositional change”

Data in Brief, 2023
Raw data obtained by ultra-high pressure liquid chromatography–mass spectrometry, and processed lipid compositional data are presented alongside detailed methodology.
Julia Bahja, Nicolas A. Stewart, Marcus K. Dymond   +2 more
doaj   +1 more source

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

eLife, 2017
Transient receptor potential (TRP) ion channels in peripheral sensory neurons are functionally regulated by hydrolysis of the phosphoinositide PI(4,5)P2 and changes in the level of protein kinase mediated phosphorylation following activation of various G
Talisia Quallo, Omar Alkhatib, Clive Gentry, David A Andersson, Stuart Bevan   +4 more
doaj   +1 more source

Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson’s disease

npj Parkinson's Disease, 2023
Pain is a key non-motor feature of Parkinson’s disease (PD) that significantly impacts on life quality. The mechanisms underlying chronic pain in PD are poorly understood, hence the lack of effective treatments.
Yazead Buhidma, Carl Hobbs, Marzia Malcangio, Susan Duty   +3 more
doaj   +1 more source

Oxidative stress is inhibited by plant-based supplements: A quantitative lipidomic analysis of antioxidant activity and lipid compositional change

Advances in Redox Research, 2022
Dietary supplements containing plant extracts are often marketed as having antioxidant properties. Using complex lipid mixtures derived from cellular tissue, we perform a targeted lipidomic assessment of the antioxidant activity of five plant extract ...
Julia Bahja, Nicolas A. Stewart, Marcus K. Dymond   +2 more
doaj   +1 more source

Drug repurposing strategies of relevance for Parkinson’s disease

Pharmacology Research & Perspectives, 2021
Parkinson's disease is a highly disabling, progressive neurodegenerative disease that manifests as a mix of motor and non‐motor signs. Although we are equipped with some symptomatic treatments, especially for the motor signs of the disease, there are ...
Edward J. R. Fletcher, Thomas Kaminski, Gareth Williams, Susan Duty   +3 more
doaj   +1 more source

Hearing impairment due to Mir183/96/182 mutations suggests both loss-of-function and gain-of-function effects

Disease Models & Mechanisms, 2021
The microRNA miR-96 is important for hearing, as point mutations in humans and mice result in dominant progressive hearing loss. Mir96 is expressed in sensory cells along with Mir182 and Mir183, but the roles of these closely-linked microRNAs are as yet ...
Morag A. Lewis, Francesca Di Domenico, Neil J. Ingham, Haydn M. Prosser, Karen P. Steel   +4 more
doaj   +1 more source

Author Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs

Scientific Data, 2020
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759 ...
Egor Marin, Aleksandra Luginina, Anastasiia Gusach, Kirill Kovalev, Sergey Bukhdruker, Polina Khorn, Vitaly Polovinkin, Elizaveta Lyapina, Andrey Rogachev, Valentin Gordeliy, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy   +12 more
doaj   +1 more source

ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice

Skeletal Muscle
Background Prior studies suggested that canonical Activin Receptor II (ActRII) and BMP receptor (BMPR) ligands can have opposing, distinct effects on skeletal muscle depending in part on differential downstream SMAD activation.
Marc A. Egerman, Yuhong Zhang, Romain Donne, Jianing Xu, Abhilash Gadi, Corissa McEwen, Hunter Salmon, Kun Xiong, Yu Bai, Mary Germino, Kevin Barringer, Yasalp Jimenez, Maria del Pilar Molina-Portela, Tea Shavlakadze, David J. Glass   +14 more
doaj   +1 more source

Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury

Lipids in Health and Disease, 2023
The miRNA-181 (miR-181) family regulates neuronal persistence during cerebral ischemia/reperfusion injury (CI/RI). Since the effect of miR-181d on CI/RI has never been studied, the current work sought to determine the involvement of miR-181d in neuronal ...
Shengnan Li, Shaofeng Chen, Yajun Wang, Xingjuan Hu, Ying Wang, Zhaochun Wu, Shaoting Huang, Jiawen He, Fu Deng, Bin Zhao, Guoda Ma, You Li   +11 more
doaj   +1 more source