Results 91 to 100 of about 132,518 (295)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Re-Thinking Ritual Traditions: Interpreting Structured Deposition in Watery Contexts in Late Pre-Roman Iron Age and Roman Britain

, 2015
This investigation seeks to define the strands of continuity and change in structured deposition across the Late Pre-Roman Iron Age to Early Roman transition in Britain, and interpret their significance in terms of cultural interaction.
Crease, SME
core  

Determinants of Smallholder Farmers’ Participation in Goat Production and Its Constraints in North Wollo Zone, Amhara Region, Ethiopia

SAGE Open
Although goat production plays a significant role in the livelihoods of smallholder farmers in Habru district, its potential to significantly improve rural livelihoods remains untapped.
Nurlgn Mohammed, Ebrahim Endris, Belete Terefe, Solomon Abegaz, Yimer Muktar, Belay Derbie, Tassew Mohammed   +6 more
doaj   +1 more source

Urban Food Crop Farming and Farm Households’ Food Security Status in Oyo State, Nigeria

Apstract: Applied Studies in Agribusiness and Commerce, 2018
Food production and supply has been on the decline in Nigeria with a consequent impact on household food security. This study examined the influence of urban farming on household food security in Oyo State, Nigeria.
David Tobi Olaleye, Abiodun Elijah Obayelu, Omotoso Oluseye Ogunmola   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Design and evaluation of bayesian optimized hybrid deep learning model for forecasting crop yields using climate dynamics

Scientific Reports
Precise crop prediction is now of utmost significance in the era of escalating climate dynamics. In this paper, a new structured Bayesian optimized hybrid deep learning model is proposed by using existing methodologies to make accurate predictions for ...
Nadia Mushtaq, Atef F. Hashem, Mahnoor Irfan, Liban Ali Mohamud   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Optimal Harvesting of Age-structured Fish Populations

A generic age-structured model for optimal harvesting is formulated and analyzed. The aim is to maximize utility from the harvest, net of effort cost. Yield depends on effort, catchability, and population age structure.
Tahvonen, Olli
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source