Results 121 to 130 of about 2,694,408 (308)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
GMA/Ag COMPOSITE AS ANTIMICROBIAL AGENT
Proceedings / 16th International Symposium "Novel Technologies and Sustainable Development"Silver, a precious metal used across various industries, can be released into the environment as a byproduct of industrial activities, potentially leading to environmental pollution. Consequently, removing silver from wastewater is crucial for enhancing environmental quality. Porous synthetic polymers (composites), with their high specific surface area
Sandra Bulatović +5 more
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Journal of Functional Morphology and KinesiologyBackground: Sleep plays a crucial role in the health of older adults, and its quality is influenced by multiple physiological and functional factors. However, the relationship between sleep quality and physical fitness, body composition, and metabolic ...
Pedro Forte +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Governance & Administrative Expenses: Key Findings [PDF]
, 2010 Board Composition & Compensation enables grantmakers to benchmark their board composition against peers in the fi eld by board member age, gender, race/ethnicity, family membership, and other characteristics.
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Ecology and conservation of bryophytes and lichens on Fagus sylvatica [PDF]
, 2009 Environmental factors related to the occurrence of epiphytic bryophytes and lichens were examined in beech (Fagus sylvatica) forests in the Province of Halland, Sweden.
Fritz, Örjan
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Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source