Results 111 to 120 of about 26,929,049 (408)

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

open access: yesFEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee   +4 more
wiley   +1 more source

Investigating the spectral age problem with powerful radio galaxies [PDF]

open access: yes, 2019
The 'spectral age problem' is our systematic inability to reconcile the maximum cooling time of radiating electrons in the lobes of a radio galaxy with its age as modelled by the dynamical evolution of the lobes. While there are known uncertainties in the models that produce both age estimates, `spectral' ages are commonly underestimated relative to ...
arxiv   +1 more source

Coupled Hydro-Mechanical Aging Of Short Flax Fiber Reinforced Composites [PDF]

open access: yesPolymer Degradation and Stability, Elsevier, 2016, 130, pp.300 - 306, 2018
One of the challenges in the widespread use of biocomposites for engineering applications is the influence of environmental conditions on their mechanical properties, particularly for a combination of aging factors such as temperature, moisture, and mechanical stresses.
arxiv   +1 more source

Factors Affecting Age at ASD Diagnosis in UK: No Evidence that Diagnosis Age has Decreased Between 2004 and 2014

open access: yesJournal of Autism and Developmental Disorders, 2016
Clinical initiatives have aimed to reduce the age at ASD diagnosis in the UK. This study investigated whether the median age at diagnosis in childhood has reduced in recent years, and identified the factors associated with earlier diagnosis in the UK ...
Denise Brett   +3 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard   +7 more
wiley   +1 more source

Introduction and reconciliation of the ROS and aging paradoxes [PDF]

open access: yesarXiv, 2017
This paper suggests that aging is influenced synthetically by pro-aging factors such as ROS and anti-aging factors such as protective responses. The anti-aging effect may be side effects of retrograde responses motivated against adverse circumstances. ROS may be more closely correlated with metabolism rather than aging.
arxiv  

The Relationship between Accretion Disc Age and Stellar Age and its Consequences for Proto-Stellar Discs [PDF]

open access: yes, 2011
We show that for young stars which are still accreting and for which measurements of stellar age, disc mass and accretion rate are available, nominal disc age (Disc Age = Disc Mass / Accretion Rate) is approximately equal to the stellar age, at least within the considerable observational scatter.
arxiv   +1 more source

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti   +2 more
wiley   +1 more source

Menstrual cycle patterns of college students in Gorgan-Northeast of Iran: Identify its association with sociodemographic factors [PDF]

open access: yes, 2009
Purpose: The menstrual cycle is used as a sign of women's health. Objective of study is determining the current menstrual patterns of students in Gorgan-Northeast of Iran, and evaluation of affecting factors on the cycle.
Gharravi, A.M.
core  

Detection of risk factors for obesity in early childhood with quantile regression methods for longitudinal data [PDF]

open access: yes, 2008
This article compares and discusses three different statistical methods for investigating risk factors for overweight and obesity in early childhood by means of the LISA study, a recent German birth cohort study with 3097 children.
Fahrmeir, Ludwig   +3 more
core   +1 more source

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