Results 141 to 150 of about 21,881,205 (365)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
MyTimeMachine: Personalized Facial Age Transformation [PDF]
arXivFacial aging is a complex process, highly dependent on multiple factors like gender, ethnicity, lifestyle, etc., making it extremely challenging to learn a global aging prior to predict aging for any individual accurately. Existing techniques often produce realistic and plausible aging results, but the re-aged images often do not resemble the person's ...
arxiv
Separating the signal from the noise: Evidence for deceleration in old-age death rates [PDF]
arXiv, 2017 Widespread population aging has made it critical to understand death rates at old ages. However, studying mortality at old ages is challenging because the data are sparse: numbers of survivors and deaths get smaller and smaller with age. We show how to address this challenge by using principled model selection techniques to empirically evaluate ...
arxiv
Volcanic dust and other factors in the production of climatic changes, and their possible relation to ice ages [PDF]
, 1913 W. J. Humphreys
openalex +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Decorrelated Adversarial Learning for Age-Invariant Face Recognition [PDF]
arXiv, 2019 There has been an increasing research interest in age-invariant face recognition. However, matching faces with big age gaps remains a challenging problem, primarily due to the significant discrepancy of face appearances caused by aging. To reduce such a discrepancy, in this paper we propose a novel algorithm to remove age-related components from ...
arxiv
AGING AS A FACTOR IN THE RENAL HEMODYNAMIC CHANGES INDUCED BY A STANDARDIZED PYROGEN [PDF]
, 1951 Roger K. McDonald +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
GASTRIC ACIDITY: RELATION TO VARIOUS FACTORS SUCH AS AGE AND PHYSICAL FITNESS [PDF]
, 1928 Arthur L. Bloomfield, Chester S. Keefer
openalex +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source