Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Risk factors of venous thromboembolism in ICU patients: a systematic review and meta-analysis. [PDF]
Ann MedYang X, Zhou X, Qiu Y.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Risk Factors and Pregnancy Outcomes of Twin Pregnancies With Gestational Diabetes Mellitus: A Comparison Based on Chorionicity. [PDF]
J Diabetes ResHuang S +6 more
europepmc +1 more source
Prevalence and Factors of Pregnancy Termination Among Reproductive-Aged Women: Evidence from the Bangladesh Demographic and Health Survey [PDF]
Md. Rabiul Islam +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Risk Factors Associated With Sarcopenia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. [PDF]
J Cachexia Sarcopenia MuscleJin K +6 more
europepmc +1 more source
P1214 Too Many Couch Potatoes Among Middle-Aged Inflammatory Bowel Disease Patients! Findings From the “BE-FIT-IBD-2” Study on Patient-Reported Physical Activity Levels Examining Their Interactions with IBD-Related Factors and Barriers/Facilitators [PDF]
Antonietta Gerarda Gravina +7 more
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Association Between Neutrophil Percentage-Albumin Ratio and Biological Aging in Rheumatoid Arthritis in the United States: A Cross-Sectional Study of NHANES. [PDF]
Mediators InflammXu Y +8 more
europepmc +1 more source