Results 51 to 60 of about 26,204,504 (362)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

EBV changes due to different age adjustment factors in the Italian Friesian [PDF]

, 1998
Mature equivalent productions are often used as input for breeding values estimation. Adjustment factors can affect genetic trend, thus efforts should be put in order to verily projected production. Adjustment factors used in different countries refer to
A. Bagnato, F. Canavesi
core  

Age group, location or pedagogue: factors affecting parental choice of kindergartens in Hungary [PDF]

, 2015
Hungary has experienced significant political, economic, demographic and social changes since the end of Soviet domination in the 1990s. The gradual move towards liberal-democracy has been accompanied by growing emphasis on individualism, choice and ...
Adelman C., Anderson R. H., Bakonyi A., British Education Research Association, Da Silva L., Dahlberg G., de Lemos M., Denise Hevey, Eleonora Teszenyi, Elfer P., Elfer P., Fenech M., Gray P., Harris N., Hungarian Academy of Sciences (HAS), Hungarian Ministry of Culture and Education, Isaacs B., Katz L., KovácsnéBakosi É., Ministry of Human Resources, Ministry of Human Resources, Moss P., Nagy Varga A., Nicol J., Nyitrai Á., Organisation for Economic Co-operation and Development, Paszkosz A., Qvortrup J., Robinson K., Sosinsky L. S., Villányi J., Woodhead M., Yin R. K., Zsolnai A.   +33 more
core   +1 more source

Age dependency of risk factors for cognitive decline

BMC Geriatrics, 2018
BackgroundRisk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55–85 years at baseline.MethodsWe included ...
N. Legdeur, M. Heymans, H. Comijs, M. Huisman, M. Huisman, A. Maier, A. B. Maier, P. Visser, P. Visser   +8 more
semanticscholar   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies

International Journal of Molecular Sciences, 2020
Gastric cancer (GC) is one of the most common malignancies worldwide and it is the fourth leading cause of cancer-related death. GC is a multifactorial disease, where both environmental and genetic factors can have an impact on its occurrence and ...
J. Machlowska, J. Baj, M. Sitarz, R. Maciejewski, R. Sitarz   +4 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Factors Affecting Age at ASD Diagnosis in UK: No Evidence that Diagnosis Age has Decreased Between 2004 and 2014

Journal of Autism and Developmental Disorders, 2016
Clinical initiatives have aimed to reduce the age at ASD diagnosis in the UK. This study investigated whether the median age at diagnosis in childhood has reduced in recent years, and identified the factors associated with earlier diagnosis in the UK ...
Denise Brett, F. Warnell, H. McConachie, J. Parr   +3 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Effect of parity in age adjustment factors in the Italian Holstein Friesian cattle breed [PDF]

, 1994
Inclusion of parity in multiplicative adjustment factors for age at calving was investigated for the Italian Holstein Friesian cattle breed. Separated age adjustment factors for first, second, third and later parities are necessary because cows of the ...
A. Bagnato, F. Canavesi, P. Rozzi
core