Results 141 to 150 of about 4,208,744 (311)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Age of Information-Aware Networks for Low-Power IoT Sensor Applications

open access: yesIoT
The Internet of Things (IoT) is a fast-growing field that has found a variety of applications, such as smart agriculture and industrial processing. In these applications, it is important for nodes to maximize the amount of useful information transmitted ...
Frederick M. Chache   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Non-stationary MAB based access method for heterogeneous users in LEO satellite systems

open access: yesTongxin xuebao
Provided that both throughput-sensitive and delay-sensitive users access the low earth orbit (LEO) satellite system simultaneously, a non-orthogonal multiple access (NOMA) access method using non-stationary multi-armed bandit (MAB) was proposed to ...
LIN Min   +4 more
doaj  

Joint Beamforming, Scheduling, Trajectory, and Transmit Power Optimization in UAV-Assisted ISAC Systems for Information Freshness

open access: yesIEEE Access
In this paper, we consider a system that integrates an unmanned aerial vehicle (UAV) for sensing and communication. The UAV is responsible for communication with multiple users and sensing targets for multiple users.
Yuting He   +5 more
doaj   +1 more source

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