Results 131 to 140 of about 5,400,886 (261)

Depopulation in the Visok micro-region: Toward demographic and economic revitalization

Open Geosciences
The demographic potential of the settlements in the Visok micro-region has been significantly disrupted since 1948. The latest census (2022) shows that the Visok micro-region now consists of very small settlements, all with fewer than 100 inhabitants. In
Marković Ksenija, Radivojević Aleksandar R., Marković Rastko S.   +2 more
doaj   +1 more source

The interplay between age structure and cultural transmission. [PDF]

PLoS Comput Biol, 2023
Kandler A, Fogarty L, Karsdorp F.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The importance of being mature: the effect of demographic maturation on global per-capita GDP [PDF]

Given that savings behaviour and worker productivity have strong life-cycle components and given that demographic profiles vary across countries, population age structure should be linked to differences in levels of economic development. In this paper we
Gómez, Rafael, Hernández de Cos, Pablo
core  

Using epigenetic clocks to investigate changes in the age structure of critically endangered Māui dolphins. [PDF]

Ecol Evol, 2023
Hernandez KM, O'Neill KB, Bors EK, Steel D, Zoller JA, Constantine R, Horvath S, Baker CS.   +7 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

China's current forest age structure will lead to weakened carbon sinks in the near future. [PDF]

Innovation (Camb), 2023
Shang R, Chen JM, Xu M, Lin X, Li P, Yu G, He N, Xu L, Gong P, Liu L, Liu H, Jiao W.   +11 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Global asymptotic stability in a pseudorabies virus model with age structure. [PDF]

Infect Dis Model, 2023
Chen Y, Long Y, Yu J.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source