Results 111 to 120 of about 5,400,886 (261)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Family Structure, Early Sexual Behavior, and Premarital Births [PDF]
In this paper, we argue that entry into first sexual intercourse is a key process mediating the effects of family structure on premarital childbearing. We explicate three ways in which onset of sexual activity can mediate effects of family structure on ...
A. J. Cherlin, L. L. Bumpass, L. L. Wu
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Impact of distance determinations on Galactic structure. II. Old tracers
, 2018 Here we review the efforts of a number of recent results that use old tracers to understand the build up of the Galaxy. Details that lead directly to using these old tracers to measure distances are discussed.
Bono, G. +16 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
PopulationsThis study adheres to a logistic regression modeling protocol originally developed for long-range intelligence analyses and employs data from UN demographic estimates (the 2024 revision) to generate a set of statistical functions that suggest a ...
Richard Cincotta
doaj +1 more source
Population Age structure and the budget deficit [PDF]
The author focuses on the effects of age structure changes on the size of budget deficits of national governments. More specifically, he determines whether differences in age structure can account for the observed differences in budget deficits across ...
Chen, Derek H. C.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Immigration, Labour Force, and the Age Structure of the Population [PDF]
The paper explores the effects of immigration on the rates of growth of the population and labour force and on the age distribution and dependency relations within the population.
Byron G. Spencer +2 more
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