Results 211 to 220 of about 7,426,653 (346)

<i>In situ</i> mechanical behavior of mineralized collagen fibrils in murine cortical bone is altered by aging and disuse. [PDF]

PeerJ
Li F, Liu F, Ren C, Zhang S, Wang Z, Yang P.   +5 more
europepmc   +1 more source

Sleep and cognitive aging in the eighth decade of life [PDF]

, 2019
Simon R. Cox, Stuart J. Ritchie, Mike Allerhand, Saskia P. Hagenaars, Ratko Radaković, David P. Breen, Gail Davies, Renata L. Riha, Sarah E. Harris, John M. Starr, Ian J. Deary   +10 more
openalex   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Sex-Specific Associations Between Anthropometric Indices and Left Ventricular Hypertrophy in Middle-Aged and Elderly Individuals with Type 2 Diabetes Mellitus. [PDF]

Diabetes Metab Syndr Obes
Liu G, Tian Q, Cui Q, Zhang R, Wang C, Fang D, Sun Z, Zou D, Chen X, Zheng R, Yuan X.   +10 more
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Effects of even- versus uneven-aged tree species (<i>Pinus massoniana</i> and <i>Castanopsis hystrix</i>) mixing on microbial communities across bulk soil, rhizosphere soil, and fine roots. [PDF]

Front Microbiol
Liu R, Bai Y, He P, Cen Q, Luo X, Yang L, Ming A, Shu W, Shen W.   +8 more
europepmc   +1 more source

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain [PDF]

, 2018
Alexandria Tartt, Camille Fulmore, Yan Liu, Gorazd Rosoklija, Andrew J. Dwork, Victoria Arango, René Hen, J. John Mann, Maura Boldrini   +8 more
openalex   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Theories of Aging: An Ever-Evolving Field

, 2015
Петр В. Сергиев, Olga А. Dontsova, Grigory V. Berezkin   +2 more
openalex   +1 more source