Results 211 to 220 of about 15,372,764 (357)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Intact corticostriatal function in aged system x_c^- - deficient mice. [PDF]

Transl Psychiatry
De Pauw L, Villers A, Moore C, Lara O, Vanonckelen O, Verbruggen L, Sato H, Bentea E, Arckens L, Ris L, Ates G, Meshul CK, Massie A.   +12 more
europepmc   +1 more source

Evaluation of Antioxidant Effects of Pumpkin (Cucurbita pepo L.) Seed Extract on Aging- and Menopause-Related Diseases Using Saos-2 Cells and Ovariectomized Rats [PDF]

Joohee Oh, Sookyeong Hong, Seong‐Hee Ko, Hyun‐Sook Kim   +3 more
openalex   +1 more source

An Age-Adjusted EEG Source Classifier Accurately Detects School-Aged Barbadian Children That Had Protein Energy Malnutrition in the First Year of Life [PDF]

, 2019
María L. Bringas-Vega, Yanbo Guo, Qin Tang, Fuleah A. Razzaq, Ana Calzada Reyes, Peng Ren, Deirel Paz-Linares, Lídice Galán García, Arielle G. Rabinowitz, Janina R. Galler, Jorge Bosch‐Bayard, Pedro A. Valdés‐Sosa   +11 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging [PDF]

Gonzalo Soto‐Heredero, Enrique Gabandé‐Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M. Gómez de las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva María Blanco, Álvaro Fernández-Almeida, David Abia, María Josefa Rodríguez, Cristina M. Fernández-Díaz, María Beatriz Álvarez Flores, Ana Ramı́rez de Molina, Sascha Jung, Antonio del Sol, Virginia Zorita, Fátima Sánchez‐Cabo, Carlos Torroja, Marı́a Mittelbrunn   +19 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling. [PDF]

Nat Commun
Ontiveros CO, Garcia MG, Murray CE, Deng Y, Bai H, Tanner C, Leung B, Li X, Padron A, Reyes RM, Kancharla A, Soh KT, Krishnan S, Chand D, Balasubramanian A, Hegner C, Jakubzick CV, Gupta HB, Turk MJ, Sundrud M, Conejo-Garcia JR, Curiel TJ.   +21 more
europepmc   +1 more source

Establishing Normal Serum Values of Neurofilament Light Chains and Glial Fibrillary Acidic Protein Considering the Effects of Age and Other Demographic Factors in Healthy Adults [PDF]

Alexander Rodero-Romero, Enric Monreal, Raquel Sainz-Amo, José Manuel García‐Domínguez, Noelia Villarrubia, José Luís Veiga-González, José Ignacio Fernández-Velasco, Haydee Goicochea-Briceño, Fernando Rodríguez‐Jorge, Susana Sainz de la Maza, Juan Luis Chico‐García, Alfonso Muriel, Jaime Masjuán, Lucienne Costa‐Frossard, Luisa María Villar   +14 more
openalex   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source