Results 121 to 130 of about 2,571,872 (312)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Comparison of Radical Cystectomy with Conservative Treatment in Geriatric ( 80) Patients with Muscle-Invasive Bladder Cancer

International Brazilian Journal of Urology, 2013
Introduction The aim of this study was to compare overall survival in elderly patients (≥ 80 years) with muscle-invasive bladder cancer (MIBC) undergoing either radical cystectomy (RC) or conservative treatment.
Thomas Martini, Roman Mayr, Clemens Wehrberger, Christopher Dechet, Michele Lodde, Salvatore Palermo, Emanuela Trenti, Evi Comploj, Armin Pycha   +8 more
doaj   +1 more source

COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes-Six Pandemic Waves: OCTA-COVID Study. [PDF]

Int J Environ Res Public Health, 2022
Ruiz-Huerta C, Canto MV, Ruiz C, González I, Lozano-Montoya I, Quezada-Feijoo M, Gómez-Pavón FJ.   +6 more
europepmc   +1 more source

Patient-centred ambulatory healthcare for people aged 80 and over

, 2023
People aged 80 and over are the fastest-growing age group in most industrialised countries. On average, this life phase is characterised by a significantly higher burden of morbidity, limitations in daily activities, medical and dental treatment needs and phenomena such as multimorbidity and frailty.
openaire   +1 more source

Postoperative complications and prognosis in patients aged over 80 undergone gastroenterological surgery.

The Japanese Journal of Gastroenterological Surgery, 1990
過去5年間に経験した80歳以上の消化器疾患全身麻酔手術例58例を対象に, 術後合併症, 予後に影響を及ぼす因子など, 高齢者手術例の臨床的特徴につき検討した. 80歳以上は全体の5.7%を占めその割合は増加傾向にあった. 疾患内容は悪性疾患が69.0%と多く, また緊急手術率は15.5%で胆管炎や腹膜炎などの感染を合併しているものが大半を占めていた. 41.4%に術後合併症を認め, 出血, 敗血症, 縫合不全などの重篤な合併症を有した3例が直死した.
Mitsuharu Nakamoto, Tomoaki Urakawa, Kiyoshi Uematsu   +2 more
openaire   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Providing ambulatory healthcare for people aged 80 and over: Views and perspectives of physicians and dentists from a qualitative survey. [PDF]

PLoS One, 2022
Herrler A, Valerius L, Barbe AG, Vennedey V, Stock S.   +4 more
europepmc   +1 more source

Suprascapular Nerve Block for Hemiplegic Shoulder Pain Post Stroke: Subgroup Analysis of Pain Response [PDF]

, 2015
This is an open access article. Open Access Journals by Jacobs Publishers is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Background and Aims: Suprascapular nerve block is an effective intervention for hemiplegic ...
Adey-Wakeling, Zoe, Crotty, Maria, Liu, Enwu, Shanahan, Ernst Michael   +3 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Geographical distribution of centenarians in Colombia: an analysis of three databases

Revista de la Facultad de Medicina, 2017
Introduction: Individuals aged one hundred years or more are of interest for the study of the aging process, which has been scarcely addressed in Colombia.
Diego Rosselli, Daniela Yucumá, María José Polanía, Jenny Carolina Machado   +3 more
doaj   +1 more source