Results 61 to 70 of about 2,393,425 (335)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Prevalência de fragilidade em uma população de longevos na região Sul do Brasil

Saúde em Debate
RESUMO Objetiva investigar a prevalência de fragilidade em uma população de longevos. Estudo observacional e transversal com idosos acima de 80 anos de um município da região Sul do Brasil.
Taís Elizabete Manfio Liberalesso, Fernanda Dallazen, Vanessa Adelina Casali Bandeira, Evelise Moraes Berlezi   +3 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice [PDF]

, 2014
BACKGROUND:Mice with conditional, intestine-specific deletion of microsomal triglyceride transfer protein (Mttp-IKO) exhibit a complete block in chylomicron assembly together with lipid malabsorption.
Breed, Elise R, Burd, Eileen M, Coopersmith, Craig M, Davidson, Nicholas O, Dominguez, Jessica A, Farris, Alton B, Liang, Zhe, Xie, Yan, Yoseph, Benyam P   +8 more
core   +3 more sources

Time trends in hospital discharges in patients aged 85 years and older in Spain: data from the Spanish National Discharge Database (2000–2015)

BMC Geriatrics, 2021
Background The aging population is an increasing concern in Western hospital systems. The aim of this study was to describe the main characteristics and hospitalization patterns in inpatients aged 85 years or more in Spain from 2000 to 2015.
Sergio Palacios-Fernandez, Mario Salcedo, Gregorio Gonzalez-Alcaide, Jose-Manuel Ramos-Rincon   +3 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Are GPs under-investigating older patients presenting with symptoms of ovarian cancer? Observational study using General Practice Research Database [PDF]

, 2010
Background: Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts.
A Majeed, A Moran, A Nicholson, A Quaglia, A R Tate, AL Hansell, C Bouchardy, C Falandry, F Berrino, J A Cassell, J Adams, J De Rijke, JMJ Kirwan, K Haynes, M Peake, N Turner, R Jones, R Neal, R Robertson, SW Pascoe, VL Allgar, W Hamilton   +21 more
core   +3 more sources

Central nervous system relapse in patients over 80 years with diffuse large B‐cell lymphoma: an analysis of two LYSA studies

Cancer Medicine, 2018
CNS relapse is reported in 2–5% of diffuse large B‐cell lymphoma (DLBCL) patients, dramatically decreasing overall survival (OS). Very few studies address incidence and risk factors of CNS relapse in very elderly patients, a challenging population to ...
Aurélie Cabannes‐Hamy, Frederic Peyrade, Fabrice Jardin, Jean‐François Emile, Vincent Delwail, Nicolas Mounier, Corinne Haioun, Aurore Perrot, Olivier Fitoussi, Diane Lara, Richard Delarue, Marc André, Fritz Offner, Hervé Ghesquières, Laurent Pascal, Carole Soussain, Julien Lazarovici, Jean‐Marc Schiano, Philippe Gaulard, Hervé Tilly, Catherine Thieblemont, the LYSA, the lymphoma study association   +22 more
doaj   +1 more source

Safety of Percutaneous Endoscopic Gastrostomy Tubes in Centenarian Patients [PDF]

Clinical Endoscopy, 2018
Background/Aims Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, no study has evaluated the safety of PEG tube placement in patients over the age of 100 years.
Zain A Sobani, Kevin Tin, Steven Guttmann, Anna A Abbasi, Ira Mayer, Yuriy Tsirlin   +5 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source