Results 81 to 90 of about 2,584,660 (392)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

PHYSIOTHERAPY IN PERSONS OVER 80 YEARS OF AGE

, 2017
Abstract Persons older than 80 are a significant group of patients in outpatient clinics.The aim of the study was to evaluate the effect of physiotherapeutic treatment of pain experienced by geriatric patients and to evaluate the basic activities in their daily lives before and after the 10 days improvement of the elderly during ambulatory treatment ...
Szczegielniak, Jan, Bogacz, Katarzyna, Matelonek, Dagmara   +2 more
openaire   +1 more source

Factors associated with sarcopenia in subjects aged 80 years and over

, 2015
OBJECTIVE: To analyze whether sarcopenia is associated with sociodemographic factors and chronic noncommunicable diseases in adults aged 80 years and older. METHODS: The sample consisted of 120 adults aged 80 to 95 years (83.4±2.9 years) from the city of
V. R. Santos, D. Christofaro, I. C. Gomes, R. Agostinete, I. F. F. Júnior, L. Gobbo   +5 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Is Spinal Surgery Safe for Elderly Patients Aged 80 and Above? Predictors of Mortality and Morbidity in an Asian Population [PDF]

Neurospine, 2019
Objective We aimed to determine the 2-year mortality and morbidity rates following spine surgery in elderly patients (age ≥80 years) and to study the associated risk factors.
Joshua Yuan-Wang Tan, Arun-Kumar Kaliya-Perumal, Jacob Yoong-Leong Oh   +2 more
doaj   +1 more source

An approach to vehicle design: in-depth audit to understand the needs of older drivers [PDF]

, 2016
The population of older people continues to increase around the world, and this trend is expected to continue; the population of older drivers is increasing accordingly.
Gyi, DE, Karali, S, Mansfield, NJ
core   +1 more source

Factors Associated with the Risk of Falls of Nursing Home Residents Aged 80 or Older

Rehabilitation Nursing, 2016
Background: Falls are the leading cause of mortality and morbidity in older and represents one of the major and most costly public health problems worldwide.
F. Á. Barbosa, B. del Pozo-Cruz, J. del Pozo-Cruz, R. Alfonso-Rosa, Borja Sañudo Corrales, M. Rogers   +5 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Relationship between obesity, sarcopenia, sarcopenic obesity, and bone mineral density in elderly subjects aged 80 years and over

Revista Brasileira de Ortopedia
Objective This study sought to analyze the relationship between the components and aggravations of body composition (obesity, sarcopenia, and sarcopenic obesity) and bone mineral density in elderly subjects aged ≥80 years.
Vanessa Ribeiro dos Santos, Diego Giulliano Destro Christofaro, Igor Conterato Gomes, Ismael Forte Freitas Júnior, Luís Alberto Gobbo   +4 more
doaj   +1 more source