Results 81 to 90 of about 2,393,425 (335)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety [PDF]

, 2010
<p>Background: Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 ...
A Brzezinski, A Chesson, AG Wade, AJ Lewy, Alan G Wade, Alex McConnachie, C Cajochen, C Liu, CA Czeisler, D Buysse, D Garfinkel, D Leger, DJ Buysse, DJ Kennaway, E Grossman, EM Gibson, G Hajak, G Mayer, Gordon Crawford, H Nakagawa, HJ Lynch, I Haimov, I Haimov, Ian Ford, IV Zhdanova, J Backhaus, JG MacFarlane, JK Wyatt, M Littner, M Littner, M Sharma, MA Hofman, MA Paul, Moshe Laudon, N Buscemi, N Zisapel, Nava Zisapel, OL Bech P, P Lemoine, P Tyrer, R Luthringer, R Mahlberg, R Mahlberg, S Ancoli-Israel, SW Lockley, T Gorfine, T Gorfine, T Roth, T Shochat, Tali Nir, W Guy, World Psychiatric Association, YH Wu   +52 more
core   +3 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Older people’s experiences of informal care in rural Flanders, Belgium [PDF]

, 2019
Flanders (Belgium) is ageing at high speed. The number of people aged over 80 will increase from more than 400.000 today to nearly 800.000 in 2060, which is 10 % of the population. Although the entire region is ageing, older people are overrepresented in
De Decker, Pascal, Schillebeeckx, Elise, Volckaert, Emma   +2 more
core   +2 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Frailsafe: from conception to national breakthrough collaborative [PDF]

, 2016
The number of people aged over 60 years worldwide is projected to rise from 605 million in 2000 to almost 2 billion by 2050, while those over 80 years will quadruple to 395 million.
Downes, Tom, Gordon, Adam L., Harriman, Paul, Hopper, Adrian, Offord, Natalie, Wyrko, Zoe   +5 more
core  

Transcutaneous vagus nerve stimulation does not affect verbal memory performance in healthy volunteers [PDF]

, 2020
Introduction: Invasive vagus nerve stimulation (VNS) improves word recognition memory in patients with epilepsy. Recent studies with transcutaneous VNS (tVNS) have also shown positive effects on various subdomains of cognitive functioning in healthy ...
Boon, Paul, Carrette, Evelien, Gadeyne, Stefanie, Mertens, Ann, Miatton, Marijke, Naert, Lien, Poppa, Tasha, Raedt, Robrecht, Vonck, Kristl   +8 more
core   +1 more source

Perception of the quality of life of caregivers of octogenarians [PDF]

Rev Rene, 2013
The objective of the study was to investigate the perception that caregivers of octogenarians have regarding the quality of life and aspects of life that are more harmful to this quality. A cross-sectional, descriptive and quantitative study conducted in
Camila Alves Nogueira, Fabiana Paulino Alves, Alexsandro Silva Coura, Caroline Evelin Nascimento Kluczynik Vieira, Bertha Cruz Enders, Inacia Sátiro Xavier de França   +5 more
doaj  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source