Results 131 to 140 of about 403,137 (309)

A social return on investment analysis of the ENJOY Seniors Exercise Park IMP-ACT project: improving older people’s health through physical activity

BMC Geriatrics
Objective To establish the cost of implementation, as well as the social return-on-investment, when scaling the Seniors Exercise Park program across multiple local government areas.
Natasha K. Brusco, Marcia Fearn, Keith D. Hill, Bronwyn Dreher, Adrian Bauman, Andrew Gilbert, Sze-Ee Soh, Elissa Burton, Rachel Muoio, Pazit Levinger   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A model of spirituality for ageing Muslims [PDF]

, 2015
Spirituality’s influence on general well-being and its association with healthy ageing has been studied extensively. However, a different perspective has to be brought in when dealing with spirituality issues of ageing Muslims.
Mahjabeen Ahmad, Shamsul Khan
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

New Comprehensive and International View on Ageing: The Survey of Health, Ageing and Retirement in Europe [PDF]

This paper introduces the ‘Survey of Health, Ageing and Retirement in Europe’ (SHARE). The 2004 baseline study collects data on the individual life circumstances of about 27,000 persons aged 50 and over in 11 European countries, ranging from Scandinavia ...
Hendrik Jürges, Karsten Hank, Axel Börsch-Supan   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The implementation of a perioperative medicine for older people undergoing surgery service: a qualitative case study

BMC Health Services Research
Background The international scale and spread of evidence-based perioperative medicine for older people undergoing surgery (POPS) services has not yet been fully realised.
Margot E Lodge, Jugdeep Dhesi, David JH Shipway, Philip Braude, Catherine Meilak, Judith Partridge, Nadine E Andrew, Velandai Srikanth, Darshini R Ayton, Chris Moran   +9 more
doaj   +1 more source

Age in an Ageing Society [PDF]

European Heart Journal, 2018
openaire   +2 more sources

Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks

, 2008
The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems.
Huba J. M. Kiss, Ágoston Mihalik, Bálint Őry, Csaba Sőti, Peter Csermely, Tibor Nánási, Zoltán Spiró   +6 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source