Results 241 to 250 of about 998,871 (360)

Molecular Mechanisms of Accelerated Ageing in Geriatric Depression: Interplay of Telomere Attrition, Mitochondrial Dysfunction and Cellular Senescence. [PDF]

Int J Mol Sci
Revi Shanker P, Dorajoo R.
europepmc   +1 more source

Circular RNAs: New players in Ageing and Age-related Chronic Disease

, 2020
Syed Ehtaishamul Haque
openalex  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Levels of active ageing and its influencing factors among older adults: a scoping review. [PDF]

BMC Public Health
Jiang J, Cheong AT, Sazlina SG, Lee K, Chu D, Yang L, Li S, Wu S, Shunmugam RH, Xu H.   +9 more
europepmc   +1 more source

The Unprecedented Growth in Medical Admissions in the UK: The Ageing Population or a Possible Infectious/Immune Aetiology?

, 2016
Rod Jones
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

We know what we need: Older adults' and stakeholders' perspectives on ageing, health, and wellbeing in Pakistan. [PDF]

PLOS Glob Public Health
Sameen S, Mansoor J, Lakhdir MPA, Asim M, Munyoki R, Greig C, Davies J, Usmani BA.   +7 more
europepmc   +1 more source

Towards Equitable Representations of Ageing: Evaluation of Gender, Territories, Aids and Artificial Intelligence [PDF]

Vanessa Zorrilla-Muñoz, Daniela Moyano, Carolina Marcos Carvajal, María Silveria Agulló Tomás   +3 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Social connections are differentially related to subjective age and physiological age acceleration amongst older adults. [PDF]

Nat Commun
Fancourt D, Steptoe A, Bloomberg M.
europepmc   +1 more source