Results 231 to 240 of about 938,839 (307)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evidence-based interventions for promoting healthy aging: a scoping review. [PDF]

J Nutr Health Aging
González-Ballesteros LM, Mojica LE, Riveros S, Zamora VV, Gómez A, Otero Rueda MDP, Chaves Matiz F, Jaimes Velásquez MA, López V, Ramírez L, Sánchez Herrera V.   +10 more
europepmc   +1 more source

Ageing phenomena (AGE): AGE summary report

, 2002
openaire   +3 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Frailty index predicts the risk of 17 health outcomes in distinct ways: prospective findings from the Moli-sani Study. [PDF]

Age Ageing
Bracone F, Di Castelnuovo A, Costanzo S, Gialluisi A, Bonaccio M, Persichillo M, De Curtis A, Magnacca S, Panzera T, Orlandi S, Cherubini A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L.   +14 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Association between electrocardiographic age and cognitive function: findings from the UK biobank and Framingham Heart Study. [PDF]

Eur Heart J Digit Health
Ofosuhene B, Ding H, Tatere HY, Vigeant TW, Li S, Bennett A, Lin H.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing. [PDF]

J Cell Mol Med
Bocca C, Boguenet M, Boucret L, Bouet PE, Reynier P, May-Panloup P.   +5 more
europepmc   +1 more source