Results 241 to 250 of about 938,839 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Correction: A care regime typology of elder, long-term care institutions. [PDF]

Eur J Ageing
van Damme M, Spijker J, Pavlopoulos D.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Crafting the ideal multidimensional active ageing intervention with wearables for older adults: insights from a qualitative study. [PDF]

BMC Geriatr
Leuzzi G, Bertoni G, Scafoglieri A, Testa M.   +3 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Association Between Metabolic Syndrome Components and Vascular Structure and Function in Subjects with a Diagnosis of Long COVID: The BioICOPER Study. [PDF]

J Clin Med
Suárez-Moreno N, Gómez-Sánchez L, Arroyo-Romero S, Navarro-Cáceres A, Domínguez-Martín A, Lugones-Sánchez C, González-Sánchez S, Sánchez-Moreno A, Rodríguez-Sánchez E, García-Ortiz L, Gómez-Marcos MA, Gómez-Sánchez M, Navarro-Matias E.   +12 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models. [PDF]

BMC Biol
McDonald DW, Chugh N, Sava R, Duennwald ML.   +3 more
europepmc   +1 more source

Navigating the Data Gaps of Ageing Among Women Living With HIV. [PDF]

J Int AIDS Soc
Sabin CA, Chandiwana N, Avihingsanon A, Policek N.   +3 more
europepmc   +1 more source

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis. [PDF]

Clin Transl Med
Zhou Y, Zhong X, Mao Z, Chen Y, Xing J, Shen J, Zhang W, Zhang J, Mei J, Yang Z, Wang Z, Ye B, Lin J, Wang Y, Huang Z.   +14 more
europepmc   +1 more source