Results 131 to 140 of about 38,974 (312)

Population ageing and public finance targets [PDF]

The paper incorporates intergenerational fairness into a framework to analyse long-term sustainability of public finances under population ageing. It establishes a link between ageing-related public expenditure projections and public finance targets ...
Heikki Oksanen
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A unifying theory of aging and mortality

Scientific Reports
Abstract In this paper, we advance the network theory of aging and mortality by developing a causal mathematical model for the mortality rate. First, we show that in large networks, where health deficits accumulate at nodes representing health indicators, the modelling of network evolution with Poisson processes is universal and can be ...
Flietner, Valentin, Heidergott, Bernd, den Hollander, Frank, Lindner, Ines, Parvaneh, Azadeh, Strulik, Holger   +5 more
openaire   +7 more sources

Should physical activity be on the healthy ageing agenda?

, 2008
Physical activity makes a notable contribution to one’s independence, ability to perform everyday tasks and quality of life in the later years, but engagement in this health-related behaviour decreases with age.
Grant, Bevan C.
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species

Nature Communications
Ageing is associated with a range of chronic diseases and has diverse hallmarks. Mitochondrial dysfunction is implicated in ageing, and mouse-models with artificially enhanced mitochondrial DNA mutation rates show accelerated ageing.
Alistair P. Green, Florian Klimm, Aidan S. Marshall, Rein Leetmaa, Juvid Aryaman, Aurora Gómez-Durán, Patrick F. Chinnery, Nick S. Jones   +7 more
doaj   +1 more source

Co-creation of social innovations for healthy ageing in rural Europe – a process evaluation of a volunteer-led guided conversation toolkit using Normalisation Process Theory (NPT)

Journal of Responsible Innovation
We critically explored the use of Normalisation Process Theory (NPT) in the evaluation of a co-designed intervention toolkit for Healthy Ageing through Innovation in Rural Europe (HAIRE).
Basharat Hussain, Mahrukh Mirza, Shukru Esmene, Catherine Leyshon, Michael Leyshon, Arunangsu Chatterjee   +5 more
doaj   +1 more source

Modernisation and ageing theory revisited: current explanations of recent developing world and historical Western shifts in material family support for older people

, 2004
Modernisation and ageing theory has provided the main platform for the debate on changes in family support for older people in both the industrialised and the developing worlds.
Aboderin, Isabella
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Positive Ageing in Place: Older Māori in Traditional and Non-traditional Place

, 2012
This thesis examines the role of place in experiences of ageing for older Māori, and the extent to which places of choice facilitate a sense of positive ageing.
Williams, Cassandra
core