Results 81 to 90 of about 5,082,581 (316)
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Inclusive learning, agentic teaching: Preparing future teachers for transformative practice
EdutecEducational transformation is crucial for the development of agency in the 21st century. Fostering the personal and professional agency of future educators prepares them to meet challenges and inspire innovation.
Erika Castro Camacho
doaj +1 more source
Agency, Empire, and the United States in Cold War Latin America [PDF]
, 2023 Thomas C. Field
openalex +1 more source
Governor’s Office of Drug Control Policy Agency Performance Reporting, 2011 [PDF]
, 2011 The Agency Performance Report for the Governor’s Office of Drug Control Policy is published in accordance with the Accountable Government Act. The information provided within this report is to aid in decision-making and to illustrate accountability to ...
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Infinite Hope: Reframing Disconnection in Emerging Adulthood Through Purpose, Agency, and Identity
Behavioral SciencesInfinite Hope (IH) is a conceptual framework designed to restore identity, direction, and resilience among disconnected emerging adults. Integrating Snyder’s Hope Theory with Sinek’s Infinite Mindset, this paper examines how cultivating an infinite ...
William Terrell Danley
doaj +1 more source
A legacy handbook for manufacturing [PDF]
, 2011 Legacy Handbook reviewing emda's experience of manufacturing activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this ...
East Midlands Development Agency, EMDA
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source