Results 101 to 110 of about 6,568,437 (291)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Combat Poverty Agency annual report 1996 [PDF]
, 1996 This report describes the work undertaken by the Agency in the past year to reduce persistent poverty and social exclusion. The Strategic Plan 1996·98 provides the framework for this work.
Combat Poverty Agency (CPA)
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Common Agency and Computational Complexity: Theory and Experimental Evidence [PDF]
In a common agency game, several principals try to influence the behavior of an agent. Common agency games typically have multiple equilibria. One class of equilibria, called truthful, has been identified by Bernheim and Whinston and has found widespread
Prat, A., Kirchsteiger, G.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Defense Logistics Agency Instruction [PDF]
, 2010 A paper that establishes Defense Logistics Agency-wide policy and directives for maintaining compliance with all environmental laws, regulations, directives, executive orders, international treatise and standards, and other controlling legal ...
United States. Defense Logistics Agency.
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THE APPROACH OF AGENCY THEORY AND THE RELATIONSHIP BETWEEN TRANSACTION COST
Sakarya Üniversitesi İktisat Dergisi, 2014 Agency theory is a concept which appears quite a lot of in modern companies. Especially in multi-partner companies and enterprises, there is a proxy noble problems and in organizations this cause transaction costs.In this study, this relationship will be
Neriman Çelik, Aykut Bedük
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Free Cash Flow, Agency Theory Dan Signaling Theory: Konsep dan Riset Empiris
Journal of Accounting and Investment, 2016 This paper discusses the literature on free cash flow (FCF), which is one source of corporate funding that can be distributed to investors after finance all investments with positive NPV.
Syukriy Abdullah
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